Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Initial adequate anti-infective therapy is associated with significantly improved clinical
outcomes for patients with severe infections. However, in critically ill patients, several …

A fundamental step in the successful management of sepsis and septic shock is early
empiric antimicrobial therapy. However, for this to be effective, several decisions must be …

Background Healthcare-associated infections involving Gram-negative bacteria (GNB) with
difficult-to-treat resistance (DTR) phenotype are associated with impaired patient-centered …

Optimization of antimicrobial dosing in accordance with pharmacokinetics/
pharmacodynamics targets can improve survival and clinical cure. Dosing regimens for …

Introduction The scope of extracorporeal membrane oxygenation (ECMO) is expanding;
however, optimal drug prescription during ECMO remains a developing science. Currently …

Pathophysiological changes during the early phase of severe sepsis and septic shock in
critically ill patients, resulting in altered pharmacokinetic (PK) patterns for antibiotics, are …

Background Optimal antibiotic exposure is a vital but challenging prerequisite for achieving
clinical success in ICU patients. Objectives To develop and externally validate a population …

Background Severe bacterial infections remain a major challenge in intensive care units
because of their high prevalence and mortality. Adequate antibiotic exposure has been …

Purpose Patients admitted to intensive care unit (ICU) with Klebsiella pneumoniae infections
are characterized by high mortality. The aims of the present study were to investigate the …