Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: an overview of their mechanisms of action

R Poupon - Clinics and research in hepatology and …, 2012 - Elsevier
Chronic cholestasis and liver inflammation are the two main pathophysiological components
of the two major classes of disease–primary biliary cirrhosis (PBC) and primary sclerosing …

[HTML][HTML] Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis

VI Reshetnyak - World Journal of Gastroenterology: WJG, 2015 - ncbi.nlm.nih.gov
Primary biliary cirrhosis (PBC) is a chronic progressive cholestatic granulomatous, and
destructive inflammatory lesion of small intralobular and septal bile ducts, which is likely to …

Preventive administration of UDCA after liver transplantation for primary biliary cirrhosis is associated with a lower risk of disease recurrence

A Bosch, J Dumortier, D Maucort-Boulch… - Journal of …, 2015 - Elsevier
Background & Aims Recurrence of primary biliary cirrhosis (PBC) after liver transplantation
(LT) is not rare and can occasionally lead to severe graft dysfunction and retransplantation …

[PDF][PDF] Shotgun proteomics: identification of unique protein profiles of apoptotic bodies from biliary epithelial cells

A Lleo, W Zhang, WH McDonald, EH Seeley… - …, 2014 - Wiley Online Library
Shotgun proteomics is a powerful analytic method to characterize complex protein mixtures
in combination with multidimensional liquid chromatography‐tandem mass spectrometry …

[PDF][PDF] Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis

T Takahashi, T Miura, J Nakamura, S Yamada… - …, 2012 - Wiley Online Library
There has been increased interest in the role of B cells in the pathogenesis of primary biliary
cirrhosis (PBC). Although the vast majority of patients with this disease have anti …

Additive improvement induced by bezafibrate in patients with primary biliary cirrhosis showing refractory response to ursodeoxycholic acid

Y Takeuchi, F Ikeda, S Fujioka, T Takaki… - Journal of …, 2011 - Wiley Online Library
Abstract Background and Aim: Ursodeoxycholic acid (UDCA) has been widely used in the
treatment of patients with primary biliary cirrhosis (PBC). However, some patients are …

Autoantibodies to GW bodies and other autoantigens in primary biliary cirrhosis

LM Stinton, M Swain, RP Myers… - Clinical & …, 2011 - academic.oup.com
Autoantibodies to intracellular targets in mitochondria and nuclei are serological hallmarks
of primary biliary cirrhosis (PBC). One of the most recently identified cellular targets of PBC …

[HTML][HTML] Bile acids impair vaccine response in children with biliary atresia

J Liu, Y Fei, T Zhou, H Ji, J Wu, X Gu, Y Luo… - Frontiers in …, 2021 - frontiersin.org
Background Vaccination is the best way to protect children under 5 years from death or
disability. Children with biliary atresia (BA), which is the most common pediatric cholestatic …

基线IgM 水平对原发性胆汁性胆管炎治疗应答的预测价值

韩琳, 梁庆升, 谢欢, 陈英, 赵军, 张明月, 李保森… - 临床肝胆病杂志, 2022 - lcgdbzz.org
目的研究基线IgM 水平与原发性胆汁性胆管炎(PBC) 患者经熊去氧胆酸(UDCA)
治疗应答的关系. 方法回顾性分析2010 年1 月—2020 年1 月解放军总医院第五医学中心确诊的 …

[HTML][HTML] Primary biliary cirrhosis: From bench to bedside

E Kouroumalis, G Notas - World Journal of Gastrointestinal …, 2015 - ncbi.nlm.nih.gov
Primary biliary cirrhosis (PBC) is a chronic non-suppurative destructive intrahepatic
cholangitis leading to cirrhosis after a protractive non cirrhotic stage. The etiology and …