The tumor microenvironment is crucial for the growth of cancer cells, triggering particular
biochemical and physiological changes, which frequently influence the outcome of …

Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) isoforms IX and XII are overexpressed in
many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation …

Cerium-based nanoparticles (CeNPs), particularly cerium oxide (CeO2), have been studied
extensively for their antioxidant and prooxidant properties. However, their complete redox …

Introduction Hypoxic tumors, unlike normal tissues, overexpress proteins involved in oxygen
sensing, metabolism, pH regulation, angiogenesis, immunological response, and other …

Abstract α-ketoglutarate (KG), also referred to as 2-oxoglutarate, is a key intermediate of
cellular metabolism with pleiotropic functions. Cell-permeable esterified analogs are widely …

Cancer therapy has been widely associated with many challenges, including effective drug
delivery. Recently, nanotechnology-enabled drug delivery system has demonstrated to be a …