Microglia, being the resident immune cells of the central nervous system, play an important
role in maintaining tissue homeostasis and contributes towards brain development under …

The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …

In neurodegenerative diseases, microglia switch to an activated state, which results in
excessive secretion of pro-inflammatory factors. Our work aims to investigate how this …

Microglia are resident cells of the brain that regulate brain development, maintenance of
neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct …

INTRODUCTION Microglia play essential roles in central nervous system homeostasis and
influence diverse aspects of neuronal function, including refinement of synaptic networks …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …

The triggering of innate immune mechanisms is emerging as a crucial component of major
neurodegenerative diseases. Microglia and other cell types in the brain can be activated in …

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Maturation of neuronal circuits requires selective elimination of synaptic connections.
Although neuron-intrinsic mechanisms are important in this process, it is increasingly …