A new look at viruses in type 1 diabetes

HS Jun, JW Yoon - ILAR journal, 2004 - academic.oup.com
Type 1 diabetes results from the destruction of pancreatic beta cells. Genetic factors are
believed to be a major component for the development of type 1diabetes, but the …

Viral infections as potential triggers of type 1 diabetes

N Van der Werf, FGM Kroese, J Rozing… - Diabetes/metabolism …, 2007 - Wiley Online Library
During the last decades, the incidence of type 1 diabetes (T1D) has increased significantly,
reaching percentages of 3% annually worldwide. This increase suggests that besides …

[HTML][HTML] Viral trigger for type 1 diabetes: pros and cons

CM Filippi, MG von Herrath - Diabetes, 2008 - ncbi.nlm.nih.gov
The most popular hypothesis circulating within and beyond the scientific community is that
viral infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed …

Association of cytomegalovirus infection with autoimmune type 1 diabetes

CY Pak, RG Mcarthur, HM Eun, JW Yoon - The Lancet, 1988 - Elsevier
The lymphocytes from 59 newly diagnosed type 1 diabetic patients and 38 normal control
subjects were examined for the presence of human cytomegalovirus (CMV) genome by …

Streptozotocin Interactions with Pancreatic β Cells and the Induction of Insulin-Dependent Diabetes

GL Wilson, EH Leiter - The Role of Viruses and the Immune System in …, 1990 - Springer
The single most consistent finding in insulin-dependent diabetes mellitus (IDDM) is a
substantial reduction in insulin secreting f3 cells (GEPTS 1965). The pathogenic factors …

The role of viruses in type I diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals

HS Jun, JW Yoon - Diabetologia, 2001 - Springer
Type I (insulin-dependent) diabetes mellitus results from the progressive loss of pancreatic
beta cells. Environmental factors are believed to play an important part in the development …

[HTML][HTML] The etiology and pathogenesis of type 1 diabetes–A personal, non-systematic review of possible causes, and interventions

K Buschard - Frontiers in Endocrinology, 2022 - frontiersin.org
In this review after a lifelong research career, my personal opinion on the development of
type 1 diabetes (T1D) from its very start to clinical manifestation will be described. T1D is a …

Contribution of animal models to diabetes research: Its history, significance, and translation to humans

S Yagihashi - Journal of Diabetes Investigation, 2023 - Wiley Online Library
Diabetes mellitus is still expanding globally and is epidemic in developing countries. The
combat of this plague has caused enormous economic and social burdens related to a …

Interaction of insulin with Pseudomonas pseudomallei

DE Woods, AL Jones, PJ Hill - Infection and immunity, 1993 - Am Soc Microbiol
Pseudomonas pseudomallei is the causative agent of melioidosis, a disease being
increasingly recognized as an important cause of morbidity and mortality in many regions of …

[HTML][HTML] Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

K Izumi, K Mine, Y Inoue, M Teshima, S Ogawa… - Nature …, 2015 - nature.com
Accumulating evidence suggests that viruses play an important role in the development of
diabetes. Although the diabetogenic encephalomyocarditis strain D virus induces diabetes …