Conditioned pain modulation (CPM), a psychophysical paradigm that is commonly used to
infer the integrity of endogenous pain-altering systems by observation of the effect of one …

Alzheimer's disease (AD) is a progressive and deleterious neurodegenerative disease,
strongly affecting the cognitive functions and memory of seniors worldwide. Around 58% of …

Background The role of microglia in Alzheimer's disease (AD) pathogenesis is becoming
increasingly important, as activation of these cell types likely contributes to both pathological …

Acute pain serves as a protective mechanism that alerts us to potential tissue damage and
drives a behavioural response that removes us from danger. The neural circuitry critical for …

Acute pain management in children: challenges and recent imp... : Current Opinion in
Anesthesiology Acute pain management in children: challenges and recent improvements …

Sleep is a nearly ubiquitous phenomenon across the phylogenetic tree, highlighting its
essential role in ensuring fitness across evolutionary time. Consequently, chronic disruption …

Different stress models are employed to enhance our understanding of the underlying
mechanisms and explore potential interventions. However, the utility of these models …

Pain contains both sensory and affective dimensions. We identify the role of norepinephrine
in colorectal distention (sub-threshold for acute pain) induced conditioned place avoidance …

Nociception is the neuronal process of encoding noxious stimuli and could be modulated at
peripheral, spinal, brainstem, and cortical levels. At cortical levels, several areas including …

Following tissue injury, latent sensitization (LS) of nociceptive signaling can persist
indefinitely, kept in remission by compensatory µ-opioid receptor constitutive activity …