Metformin: Prevention of genomic instability and cancer: A review

M Najafi, M Cheki, S Rezapoor, G Geraily… - … /Genetic Toxicology and …, 2018 - Elsevier
The diabetes drug metformin can mitigate the genotoxic effects of cytotoxic agents and has
been proposed to prevent or even cure certain cancers. Metformin reduces DNA damage by …

The role of microRNAs in the mammary gland development, health, and function of cattle, goats, and sheep

AP Dysin, OY Barkova, MV Pozovnikova - Non-coding RNA, 2021 - mdpi.com
Milk is an integral and therefore complex structural element of mammalian nutrition.
Therefore, it is simple to conclude that lactation, the process of producing milk, is as complex …

miR-342-3p suppresses hepatocellular carcinoma proliferation through inhibition of IGF-1R-mediated Warburg effect

W Liu, L Kang, J Han, Y Wang, C Shen… - OncoTargets and …, 2018 - Taylor & Francis
Background Insulin-like growth factor-1 receptor (IGF-1R) is a well-studied oncogenic factor
that promotes cell proliferation and energy metabolism and is overexpressed in numerous …

Induction of COX-2/PGE2/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: role of TLR4-dependent NADPH oxidase activation

CC Lin, IT Lee, YL Yang, CW Lee, YR Kou… - Free Radical Biology and …, 2010 - Elsevier
Exposure to cigarette smoke extract (CSE) leads to airway and lung inflammation through an
oxidant-antioxidant imbalance. Cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) …

MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas

Z Shi, X Wang, X Qian, T Tao, L Wang, Q Chen… - Rna, 2013 - rnajournal.cshlp.org
MicroRNAs (miRNAs) are single-stranded, 18-to 23-nt RNA molecules that function as
regulators of gene expression. Previous studies have shown that microRNAs play important …

MicroRNAs as the pivotal regulators of cisplatin resistance in osteosarcoma

M Moghbeli - Pathology-Research and Practice, 2023 - Elsevier
Osteosarcoma (OS) is an aggressive bone tumor that originates from mesenchymal cells. It
is considered as the eighth most frequent childhood cancer that mainly affects the tibia and …

Targeting insulin and insulin‐like growth factor pathways in epithelial ovarian cancer

MC Beauchamp, A Yasmeen, A Knafo… - Journal of …, 2010 - Wiley Online Library
Ovarian cancer is the most lethal of all gynecological malignancies, due in part to the
diagnosis at an advanced stage caused by the lack of specific signs and symptoms and the …

RETRACTED ARTICLE: MicroRNA-133a functions as a tumor suppressor by targeting IGF-1R in hepatocellular carcinoma

W Zhang, K Liu, S Liu, B Ji, Y Wang, Y Liu - Tumor Biology, 2015 - Springer
MicroRNAs (miRNAs) are a class of small non-coding RNAs and have critical roles in
tumorigenesis and metastasis. A growing body of evidence showed that microRNA-133a …

Hydrogen-rich water mitigates LPS-induced chronic intestinal inflammatory response in rats via Nrf-2 and NF-κB signaling pathways

J Peng, Q He, S Li, T Liu, J Zhang - Veterinary Sciences, 2022 - mdpi.com
Simple Summary Our study provides substantial evidence that hydrogen-rich water can
prevent intestinal damage caused by LPS-induced stimulation. Intestinal injury caused by …

Diabetes and Ovarian cancer: risk factors, molecular mechanisms and impact on prognosis

F Karimi, N Dinarvand, M Sabaghan, O Azadbakht… - Endocrine, 2024 - Springer
Background and aim Diabetes mellitus has been linked to a lower rate of cancer survival
and an increase in the incidence of most malignancies. Investigations showed that diabetes …