The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

TP53 is the most frequently mutated tumor suppressor gene in human cancer. The majority
of mutations of p53 are missense mutations, leading to the expression of the full length p53 …

Genomic and functional study of existing and emerging sarcoma targets, such as fusion
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …

Awareness of the importance of immunity in controlling cancer development triggered
research into the impact of its key oncogenic drivers on the immune response, as well as …

Objective. To evaluate the effect of p53 on pyroptosis and its inhibitory role on tumor growth
in non-small-cell lung cancer (NSCLC). Methods. The correlation of p53 and pyroptosis was …

Continuous development of personalized treatments is undoubtedly beneficial for oncogenic
patients' comfort and survival rate. Mutant TP53 is associated with a worse prognosis due to …

The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-
function (GOF) activities that affect molecular pathways crucial for tumorigenesis and …

Simple Summary Molecular biomarkers are utilised for the development of targeted therapy
and diagnostic or prognostic tools and in strategising therapeutic approaches as they may …

Globally, pancreatic cancer (PC) is a common and highly malignant gastrointestinal tumor
that is characterized by an insidious onset and ready metastasis and recurrence. Over …