Curative therapy for sickle cell disease (SCD) currently requires gonadotoxic conditioning
that can impair future fertility. Fertility outcomes after curative therapy are likely affected by …

Currently, most men with infertility cannot be given an aetiology, which reflects a lack of
knowledge around gamete production and how it is affected by genetics and the …

The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …

Beta-thalassemia (BTH), a recessively inherited haemoglobin (Hb) disorder, causes iron
overload (IO), extra-medullary haematopoiesis and bone marrow expansion with major …

The loss of germ cells and spermatogenic failure in non-obstructive azoospermia are
believed to be the main causes of male infertility. Laboratory studies have used in vitro …

STUDY QUESTION What is the impact of cancer or hematological disorders on germ cells in
pediatric male patients? SUMMARY ANSWER Spermatogonial quantity is reduced in testes …

With advances in cancer treatment, such as cytotoxic chemotherapy and radiotherapy, grave
new sequelae of treatment have emerged for young cancer survivors. One sequela that …

This review provides an overview of reproductive and sexual healthcare concerns for
individuals with SCD and their families. Reproductive and sexual health care are …

This review aims to explore advanced reproductive technologies for male fertility
preservation, underscoring the essential role that animal models have played in shaping …

Hemoglobinopathies are autosomal recessive disorders that occur when genetic mutations
negatively impact the function of hemoglobin. Common hemoglobinopathies that are …