In the last decade, basic cancer research has produced remarkable advances in our
understanding of cancer biology and cancer genetics. Among the most important of these …

Because the discovery of a link between mismatch repair deficiency and sporadic or
inherited human cancers characterized by microsatellite instability (MSI-H tumors), genes …

Purpose: To compare microsatellite instability (MSI) testing with immunohistochemical (IHC)
detection of hMLH1 and hMSH2 in colorectal cancer. Patients and Methods: Colorectal …

Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite
instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without …

An understanding of the mechanisms that explain the initiation and early evolution of
colorectal cancer should facilitate the development of new approaches to effective …

Determining whether a tumor exhibits microsatellite instability (MSI) is useful in identifying
patients with hereditary non-polyposis colorectal cancer and sporadic gastrointestinal …

Defects in apoptosis have been implicated in chemoresistance of colon cancer cells. We
report here the ability to resist to 5‐fluorouracil‐induced apoptosis of 8 colon cancer cell …

The aim of our study was to assess the relationship between colorectal tumor
responsiveness to irinotecan and microsatellite instability (MSI), a feature of colorectal …

β-Catenin is a cytoplasmic protein that participates in the assembly of cell-cell adherens
junctions by binding cadherins to the actin cytoskeleton. In addition, it is a key component of …

Colorectal carcinomas develop according to particular genetic pathways, including the
chromosomal instability (CIN+), microsatellite instability (MSI+) and MSI− CIN− routes. We …