Major histocompatibility complex (MHC) class I and MHC class II proteins: conformational plasticity in antigen presentation
M Wieczorek, ET Abualrous, J Sticht… - Frontiers in …, 2017 - frontiersin.org
Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …
Class II MHC antigen processing in immune tolerance and inflammation
MM Jurewicz, LJ Stern - Immunogenetics, 2019 - Springer
Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …
[HTML][HTML] Crystal structure of the HLA-DM–HLA-DR1 complex defines mechanisms for rapid peptide selection
HLA-DR molecules bind microbial peptides in an endosomal compartment and present
them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the …
them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the …
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism
AI Guce, SE Mortimer, T Yoon, CA Painter… - Nature structural & …, 2013 - nature.com
Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA …
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA …
MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange
ET Abualrous, S Stolzenberg, J Sticht… - Nature Chemical …, 2023 - nature.com
Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …
HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide
AK Anders, MJ Call, MSED Schulze, KD Fowler… - Nature …, 2011 - nature.com
The mechanisms of HLA-DM-catalyzed peptide exchange remain uncertain. Here we found
that all stages of the interaction of HLA-DM with HLA-DR were dependent on the occupancy …
that all stages of the interaction of HLA-DM with HLA-DR were dependent on the occupancy …
Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I–related protein 1 MR1
The Major Histocompatibility Complex class I–related protein 1 (MR1) presents small
molecule metabolites, drugs, and drug-like molecules that are recognized by MR1-reactive T …
molecule metabolites, drugs, and drug-like molecules that are recognized by MR1-reactive T …
Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates
Background Classical major histocompatibility complex (MHC) class II molecules play an
essential role in presenting peptide antigens to CD4+ T lymphocytes in the acquired …
essential role in presenting peptide antigens to CD4+ T lymphocytes in the acquired …
Conformational variation in structures of classical and non‐classical MHCII proteins and functional implications
CA Painter, LJ Stern - Immunological reviews, 2012 - Wiley Online Library
Recent structural characterizations of classical and non‐classical major histocompatibility
complex class II (MHCII) proteins have provided a view into the dynamic nature of the MHCII …
complex class II (MHCII) proteins have provided a view into the dynamic nature of the MHCII …
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange
CA Painter, MP Negroni… - Proceedings of the …, 2011 - National Acad Sciences
HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its
mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA …
mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA …