Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …

HLA-DR molecules bind microbial peptides in an endosomal compartment and present
them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the …

Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA …

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …

The mechanisms of HLA-DM-catalyzed peptide exchange remain uncertain. Here we found
that all stages of the interaction of HLA-DM with HLA-DR were dependent on the occupancy …

The Major Histocompatibility Complex class I–related protein 1 (MR1) presents small
molecule metabolites, drugs, and drug-like molecules that are recognized by MR1-reactive T …

Background Classical major histocompatibility complex (MHC) class II molecules play an
essential role in presenting peptide antigens to CD4+ T lymphocytes in the acquired …

Recent structural characterizations of classical and non‐classical major histocompatibility
complex class II (MHCII) proteins have provided a view into the dynamic nature of the MHCII …

HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its
mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA …