The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity
Y Xiong, BB Mi, Z Lin, YQ Hu, L Yu, KK Zha… - Military Medical …, 2022 - Springer
Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …
a variety of cell types, whose activity and interplay must be precisely mediated for effective …
[HTML][HTML] Progress, opportunity, and perspective on exosome isolation-efforts for efficient exosome-based theranostics
D Yang, W Zhang, H Zhang, F Zhang, L Chen, L Ma… - Theranostics, 2020 - ncbi.nlm.nih.gov
Exosomes are small extracellular vesicles with diameters of 30-150 nm. In both
physiological and pathological conditions, nearly all types of cells can release exosomes …
physiological and pathological conditions, nearly all types of cells can release exosomes …
Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis
Y Tan, Y Huang, R Mei, F Mao, D Yang, J Liu… - Cell death & …, 2022 - nature.com
Activated hepatic stellate cells (HSCs) are significant in liver fibrosis. Our past investigations
have shown that human umbilical cord mesenchymal stem cells (hucMSCs) and their …
have shown that human umbilical cord mesenchymal stem cells (hucMSCs) and their …
Adult mesenchymal stem cells and their exosomes: Sources, characteristics, and application in regenerative medicine
M Maqsood, M Kang, X Wu, J Chen, L Teng, L Qiu - Life sciences, 2020 - Elsevier
Human mesenchymal stem cells (MSCs) have become a hot topic in the development of cell
therapies and bioengineering. All kinds of MSCs are genomic stable and have the self …
therapies and bioengineering. All kinds of MSCs are genomic stable and have the self …
miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis …
Q Qu, L Liu, Y Cui, H Liu, J Yi, W Bing, C Liu… - Stem cell research & …, 2022 - Springer
Background In our previous research, we found that overexpression of miR-126-3p in
human umbilical cord MSCs (hucMSCs) promoted human umbilical vein endothelial cells …
human umbilical cord MSCs (hucMSCs) promoted human umbilical vein endothelial cells …
MSC based therapies—new perspectives for the injured lung
J Behnke, S Kremer, T Shahzad, CM Chao… - Journal of clinical …, 2020 - mdpi.com
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …
[HTML][HTML] Extracellular vesicles: emerging tools as therapeutic agent carriers
Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …
Role of human mesenchymal stem cells in regenerative therapy
Mesenchymal stem cells (MSCs) are multipotent cells which can proliferate and replace
dead cells in the body. MSCs also secrete immunomodulatory molecules, creating a …
dead cells in the body. MSCs also secrete immunomodulatory molecules, creating a …
Stem cell therapy for COVID‐19, ARDS and pulmonary fibrosis
Z Li, S Niu, B Guo, T Gao, L Wang, Y Wang… - Cell …, 2020 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is an acute respiratory infectious disease
caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). COVID‐19 …
caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). COVID‐19 …