The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Y Xiong, BB Mi, Z Lin, YQ Hu, L Yu, KK Zha… - Military Medical …, 2022 - Springer
Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

[HTML][HTML] Progress, opportunity, and perspective on exosome isolation-efforts for efficient exosome-based theranostics

D Yang, W Zhang, H Zhang, F Zhang, L Chen, L Ma… - Theranostics, 2020 - ncbi.nlm.nih.gov
Exosomes are small extracellular vesicles with diameters of 30-150 nm. In both
physiological and pathological conditions, nearly all types of cells can release exosomes …

Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis

Y Tan, Y Huang, R Mei, F Mao, D Yang, J Liu… - Cell death & …, 2022 - nature.com
Activated hepatic stellate cells (HSCs) are significant in liver fibrosis. Our past investigations
have shown that human umbilical cord mesenchymal stem cells (hucMSCs) and their …

Adult mesenchymal stem cells and their exosomes: Sources, characteristics, and application in regenerative medicine

M Maqsood, M Kang, X Wu, J Chen, L Teng, L Qiu - Life sciences, 2020 - Elsevier
Human mesenchymal stem cells (MSCs) have become a hot topic in the development of cell
therapies and bioengineering. All kinds of MSCs are genomic stable and have the self …

miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis …

Q Qu, L Liu, Y Cui, H Liu, J Yi, W Bing, C Liu… - Stem cell research & …, 2022 - Springer
Background In our previous research, we found that overexpression of miR-126-3p in
human umbilical cord MSCs (hucMSCs) promoted human umbilical vein endothelial cells …

MSC based therapies—new perspectives for the injured lung

J Behnke, S Kremer, T Shahzad, CM Chao… - Journal of clinical …, 2020 - mdpi.com
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …

[HTML][HTML] Extracellular vesicles: emerging tools as therapeutic agent carriers

S Liu, X Wu, S Chandra, C Lyon, B Ning, J Fan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …

Role of human mesenchymal stem cells in regenerative therapy

J Vasanthan, N Gurusamy, S Rajasingh, V Sigamani… - Cells, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent cells which can proliferate and replace
dead cells in the body. MSCs also secrete immunomodulatory molecules, creating a …

Stem cell therapy for COVID‐19, ARDS and pulmonary fibrosis

Z Li, S Niu, B Guo, T Gao, L Wang, Y Wang… - Cell …, 2020 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is an acute respiratory infectious disease
caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). COVID‐19 …