The heart is the first organ to form in the embryo, and all subsequent events in the life of the
organism depend on its function. Inherited mutations in cardiac regulatory genes give rise to …

Background: Cardiovascular disease (CVD), the most common cause of death globally,
accounts for~ 30% of all deaths worldwide. Hypertension is a common contributor to …

both to Gαs and to the inhibitory G protein (Gαi), which functions, in part, to diminish adenylyl
cyclase activity and subsequent cAMP levels (Figure 1). The ß1-adrenergic receptor …

We have used chemical synthesis, functional reconstitution, and electron paramagnetic
resonance (EPR) to probe the functional dynamics of phospholamban (PLB), which …

We have used chemical synthesis and electron paramagnetic resonance to probe the
structural dynamics of phospholamban (PLB) in lipid bilayers. Derivatives of monomeric PLB …

Abstract β-adrenergic signaling is an important regulator of myocardial function. During the
progression of heart failure (HF), a reproducible series of biochemical events occurs that …

Despite recent advances in chronic heart failure (HF) management, the prognosis of HF
patients is poor. This highlights the need for researching new drugs targeting, beyond …

We used fluorescence resonance energy transfer (FRET) to detect and quantitate the
interaction of the sarcoplasmic reticulum Ca-ATPase (SERCA) with phospholamban (PLB) …

Phospholamban (PLB) and Sarcolipin (SLN) are integral membrane proteins that regulate
muscle contractility via direct interaction with the Ca-ATPase in cardiac and skeletal muscle …

Although several risk factors including hypertension, cardiac hypertrophy, coronary artery
disease, and diabetes are known to result in heart failure, elderly subjects are more …