Fibroblasts in heart scar tissue directly regulate cardiac excitability and arrhythmogenesis
Y Wang, Q Li, B Tao, M Angelini, S Ramadoss, B Sun… - Science, 2023 - science.org
After heart injury, dead heart muscle is replaced by scar tissue. Fibroblasts can electrically
couple with myocytes, and changes in fibroblast membrane potential can lead to myocyte …
couple with myocytes, and changes in fibroblast membrane potential can lead to myocyte …
Diversity of cells and signals in the cardiovascular system
This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …
Symposium on Systems Approach to Understanding Cardiovascular Disease and …
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction
SH Weinberg - Journal of General Physiology, 2023 - rupress.org
Sodium (Na+) current is responsible for the rapid depolarization of cardiac myocytes that
triggers the cardiac action potential upstroke. Recent studies have illustrated the presence of …
triggers the cardiac action potential upstroke. Recent studies have illustrated the presence of …
Patchy fibrosis promotes trigger–substrate interactions that both generate and maintain atrial fibrillation
MA Colman, R Sharma, OV Aslanidi… - Interface …, 2023 - royalsocietypublishing.org
Fibrosis has been mechanistically linked to arrhythmogenesis in multiple cardiovascular
conditions, including atrial fibrillation (AF). Previous studies have demonstrated that fibrosis …
conditions, including atrial fibrillation (AF). Previous studies have demonstrated that fibrosis …
A simple approach for image-based modelling of the heart that enables robust simulation of highly heterogeneous electrical excitation
Remodelling of cardiac tissue structure, including intercellular electrical coupling, is a major
determinant of the complex and heterogeneous excitation patterns associated with cardiac …
determinant of the complex and heterogeneous excitation patterns associated with cardiac …
Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures
Cardiomyocyte cultures exhibit spontaneous electrical and contractile activity, as in a natural
cardiac pacemaker. In such preparations, beat rate variability exhibits features similar to …
cardiac pacemaker. In such preparations, beat rate variability exhibits features similar to …
An anisotropic network model of inter-cellular coupling for robust simulation of cardiac electrical excitation in structurally complex and heterogeneous large tissue …
Inter-cellular electrical coupling in the heart is a major determinant of excitation patterns in
health and disease. Cardiac arrhythmias, in particular rapid arrhythmias such as tachycardia …
health and disease. Cardiac arrhythmias, in particular rapid arrhythmias such as tachycardia …