Nrf2–ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases
Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …
century and the second leading cause of death by 2050. The main risk factor of these …
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders
Introduction• ER stress and the UPR‐The IRE1 axis: non‐conventional splicing of XBP1
mRNA‐The PERK axis: attenuation of translation‐The ATF6 axis: regulated proteolytic …
mRNA‐The PERK axis: attenuation of translation‐The ATF6 axis: regulated proteolytic …
The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases
G Joshi, JA Johnson - Recent Patents on CNS Drug Discovery …, 2012 - ingentaconnect.com
Modulation of NF-E2 related factor 2 (Nrf2) has been shown in several neurodegenerative
disorders. The overexpression of Nrf2 has become a potential therapeutic avenue for …
disorders. The overexpression of Nrf2 has become a potential therapeutic avenue for …
The Nrf2–ARE cytoprotective pathway in astrocytes
MR Vargas, JA Johnson - Expert reviews in molecular medicine, 2009 - cambridge.org
The expression of phase-II detoxification and antioxidant enzymes is governed by a cis-
acting regulatory element named the antioxidant response element (ARE). ARE-containing …
acting regulatory element named the antioxidant response element (ARE). ARE-containing …
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients
M Mitne-Neto, M Machado-Costa… - Human molecular …, 2011 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is an incurable neuromuscular disease that leads to a
profound loss of life quality and premature death. Around 10% of the cases are inherited and …
profound loss of life quality and premature death. Around 10% of the cases are inherited and …
[HTML][HTML] Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: therapeutic modulation via fumaric acid esters
DH Lee, R Gold, RA Linker - International journal of molecular sciences, 2012 - mdpi.com
Oxidative stress plays a crucial role in many neurodegenerative conditions such as
Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's as well as Huntington's …
Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's as well as Huntington's …
[HTML][HTML] An overview on recent in vivo biological application of cerium oxide nanoparticles
BS Inbaraj, BH Chen - Asian journal of pharmaceutical sciences, 2020 - Elsevier
Cerium oxide nanoparticles (CNPs) possess a great potential as therapeutic agents due to
their ability to self-regenerate by reversibly switching between two valences+ 3 and+ 4. This …
their ability to self-regenerate by reversibly switching between two valences+ 3 and+ 4. This …
Beyond muscles: The untapped potential of creatine
LA Riesberg, SA Weed, TL McDonald… - International …, 2016 - Elsevier
Creatine is widely used by both elite and recreational athletes as an ergogenic aid to
enhance anaerobic exercise performance. Older individuals also use creatine to prevent …
enhance anaerobic exercise performance. Older individuals also use creatine to prevent …
Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up
H Deda, MC Inci, AE Kürekçi, A Sav, K Kayıhan… - …, 2009 - Taylor & Francis
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder
characterized by progressive loss of spinal cord and cortical motoneurons. Despite …
characterized by progressive loss of spinal cord and cortical motoneurons. Despite …
Therapeutic potential of short-chain fatty acid production by gut microbiota in neurodegenerative disorders
S Yadav, A Dwivedi, A Tripathi, AK Tripathi - Nutrition Research, 2022 - Elsevier
Dietary fibers are a major source of short-chain fatty acids (SCFAs) in the body, and the
fermentation products of SCFAs induced by intestinal microbiota affect energy metabolism …
fermentation products of SCFAs induced by intestinal microbiota affect energy metabolism …