Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Introduction• ER stress and the UPR‐The IRE1 axis: non‐conventional splicing of XBP1
mRNA‐The PERK axis: attenuation of translation‐The ATF6 axis: regulated proteolytic …

Modulation of NF-E2 related factor 2 (Nrf2) has been shown in several neurodegenerative
disorders. The overexpression of Nrf2 has become a potential therapeutic avenue for …

The expression of phase-II detoxification and antioxidant enzymes is governed by a cis-
acting regulatory element named the antioxidant response element (ARE). ARE-containing …

Amyotrophic lateral sclerosis (ALS) is an incurable neuromuscular disease that leads to a
profound loss of life quality and premature death. Around 10% of the cases are inherited and …

Oxidative stress plays a crucial role in many neurodegenerative conditions such as
Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's as well as Huntington's …

Cerium oxide nanoparticles (CNPs) possess a great potential as therapeutic agents due to
their ability to self-regenerate by reversibly switching between two valences+ 3 and+ 4. This …

Creatine is widely used by both elite and recreational athletes as an ergogenic aid to
enhance anaerobic exercise performance. Older individuals also use creatine to prevent …

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder
characterized by progressive loss of spinal cord and cortical motoneurons. Despite …

Dietary fibers are a major source of short-chain fatty acids (SCFAs) in the body, and the
fermentation products of SCFAs induced by intestinal microbiota affect energy metabolism …