Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …

This review discusses important advances in fungal diagnostics and in the antifungal
armamentarium as applied to aspergillus species. Recent insights concerning host defenses …

The lung naturally resists Aspergillus fumigatus (Af) in healthy individuals, but multiple
conditions can disrupt this resistance, leading to lethal invasive infections. Core processes …

The C-type lectin dectin-1 binds to yeast and signals through the kinase Syk and the adaptor
CARD9 to induce production of interleukin 10 (IL-10) and IL-2 in dendritic cells (DCs) …

The onset of the adaptive immune response to Mycobacterium tuberculosis is delayed
compared with that of other infections or immunization, and allows the bacterial population …

The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …

The pattern recognition theory proposed by the late Charles Janeway, Jr. 20 years ago
provided a conceptual framework for our current understanding of the innate immune …

Aspergillus fumigatus, a ubiquitous fungus, causes invasive disease in
immunocompromised humans. Although monocytes and antigen-specific CD4 T cells …

All humans are continuously exposed to inhaled Aspergillus conidia, yet healthy hosts clear
the organism without developing disease and without the development of antibody-or cell …

Aspergillus fumigatus is a ubiquitous saprophytic mold (67) that forms airborne spores
(conidia). Humans inhale, on average, hundreds of these infectious propagules daily. In …