There have been major changes since the incidents of leukemia development in X-SCID
patients after the treatments using retroviral gene therapy. Due to the risk of oncogenesis …

Lentiviruses induce a wide variety of pathologies in different animal species. A common
feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a …

Gene transfer vectors based on retroviruses including oncogenic retroviruses and
lentiviruses provide effective means for the delivery, integration and expression of …

Recent commercialization of lentiviral vector (LV)-based cell therapies and successful
reports of clinical studies have demonstrated the untapped potential of LVs to treat diseases …

The recent incidents of leukemia development in X-SCID patients after a successful
treatment of the disease with retroviral gene therapy raised concerns regarding the safety of …

Abstract High-titer, HIV-1–based lentiviral vector particles were found to transduce cytokine-
mobilized rhesus macaque CD34+ cells and clonogenic progenitors very poorly (< 1%) …

Recombinant retroviral vectors based upon simple gammaretroviruses, complex
lentiviruses, or potentially nonpathogenic spumaviruses represent relatively well …

Progress in developing effective gene transfer approaches to treat HIV-1 infection has been
steady. Many different transgenes have been reported to inhibit HIV-1 in vitro. However …

Despite the extensive research efforts over the past 25 years that have focused on HIV, there
is still no cure for AIDS. However, tremendous progress in the understanding of the structure …

To make human immunodeficiency virus type 1 (HIV-1)-based vectors safer for use in the
research and clinical setting, a significant modification to the HIV-1 genome has been the …