Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Cardiovascular disease (CVD) remains the leading cause of death worldwide. Natural
compounds extracted from medicinal plants characterized by diverse biological activities …

Electric pulses used in electroporation-based treatments have been shown to affect the
excitability of muscle and neuronal cells. However, understanding the interplay between …

Cardiovascular diseases are the most common cause of death globally. Accurately
modeling cardiac homeostasis, dysfunction, and drug response lies at the heart of cardiac …

Great expectations have been set around the clinical potential of regenerative and
reparative medicine in the treatment of cardiovascular diseases [ie in particular, heart failure …

Upon myocardial infarction (MI), ischemia-induced cell death triggers an inflammatory
response responsible for removing necrotic material and inducing tissue repair. TRPM4 is a …

Cardiac myocytes isolated from adult heart tissue have a rod‐like shape with highly
organized intracellular structures. Cardiomyocytes derived from human pluripotent stem …

A comprehensive understanding of the pathophysiology and cellular responses to drugs in
human heart disease is limited by species differences between humans and experimental …

The inaccessibility of human cardiomyocytes significantly hindered years of cardiovascular
research efforts. To overcome these limitations, non-human cell sources were used as …

Heart failure (HF) is one of the most critical health and economic burdens worldwide, and its
prevalence is continuously increasing. HF is a disease that occurs due to a pathological …