During almost 40 years of use, the micronucleus assay (MN) has become one of the most
popular methods to assess genotoxicity of different chemical and physical factors, including …

Biological dosimetry, based on the analysis of micronuclei (MN) in the cytokinesis-block
micronucleus (CBMN) assay can be used as an alternative method for scoring dicentric …

Micronuclei (MN) are small, extranuclear bodies that arise in dividing cells from acentric
chromosome/chromatid fragments or whole chromosomes/chromatids lagging behind in …

Radiation-induced chromosomal aberrations represent an early marker of late effects,
including cell killing and transformation. The measurement of cytogenetic damage in tissues …

With the growing numbers of nanomaterials (NMs), there is a great demand for rapid and
reliable ways of testing NM safety—preferably using in vitro approaches, to avoid the ethical …

Attrition due to nonclinical safety represents a major issue for the productivity of
pharmaceutical research and development (R&D) organizations, especially during the …

In vitro genotoxicity testing needs to include tests in both bacterial and mammalian cells, and
be able to detect gene mutations, chromosomal damage and aneuploidy. This may be …

Following a mass-casualty nuclear disaster, effective medical triage has the potential to save
tens of thousands of lives. In order to best use the available scarce resources, there is an …

Nanomaterials have outstanding and unprecedented advantageous material properties but
may also cause adverse effects in humans upon exposure. Testing nanomaterials for …

The cytokinesis-block micronucleus cytome (CBMN Cyt) assay is one of the best-validated
methods for measuring chromosome damage in human lymphocytes. This paper describes …