[HTML][HTML] Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification
P Augsornworawat, NJ Hogrebe, M Ishahak… - Nature Cell …, 2023 - nature.com
Insulin-producing β cells created from human pluripotent stem cells have potential as a
therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC …
therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC …
Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes
Islet transplantation holds significant promise as a curative approach for type 1 diabetes
(T1D). However, the transition of islet transplantation from the experimental phase to …
(T1D). However, the transition of islet transplantation from the experimental phase to …
[HTML][HTML] Subcutaneous device-free islet transplantation
X Zhou, Z Xu, Y You, W Yang, BZ Feng… - Frontiers in …, 2023 - frontiersin.org
Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it
affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is …
affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is …
Immunomodulation by subcutaneously injected methacrylic acid-based hydrogels and tolerogenic dendritic cells in a mouse model of autoimmune diabetes
SM Kinney, K Ortaleza, SY Won, BJM Licht, MV Sefton - Biomaterials, 2023 - Elsevier
Type 1 diabetes is an autoimmune disease associated with the destruction of insulin-
producing β cells. Immunotherapies are being developed to mitigate autoimmune diabetes …
producing β cells. Immunotherapies are being developed to mitigate autoimmune diabetes …
Bioengineering and vascularization strategies for islet organoids: advancing toward diabetes therapy
J Yang, Y Yan, X Yin, X Liu, IV Reshetov, PA Karalkin… - Metabolism, 2024 - Elsevier
Diabetes presents a pressing healthcare crisis, necessitating innovative solutions. Organoid
technologies have rapidly advanced, leading to the emergence of bioengineering islet …
technologies have rapidly advanced, leading to the emergence of bioengineering islet …
[HTML][HTML] Global research trends of diabetes remission: a bibliometric study
X Yang, Z He, Q Chen, Y Chen, G Chen… - Frontiers in …, 2023 - frontiersin.org
Background Research on diabetes remission has garnered prominence in recent years.
However, to date, no pertinent bibliometric study has been published. This study sought to …
However, to date, no pertinent bibliometric study has been published. This study sought to …
LINC MIR503HG Controls SC‐β Cell Differentiation and Insulin Production by Targeting CDH1 and HES1
Y Xu, S Mao, H Fan, J Wan, L Wang… - Advanced …, 2024 - Wiley Online Library
Stem cell‐derived pancreatic progenitors (SC‐PPs), as an unlimited source of SC‐derived β
(SC‐β) cells, offers a robust tool for diabetes treatment in stem cell‐based transplantation …
(SC‐β) cells, offers a robust tool for diabetes treatment in stem cell‐based transplantation …
Human A2-CAR T cells reject HLA-A2+ human islets transplanted into mice without inducing graft-versus-host disease
CE Ellis, M Mojibian, S Ida, VCW Fung, S Skovsø… - …, 2023 - journals.lww.com
Background. Type 1 diabetes is an autoimmune disease characterized by T-cell–mediated
destruction of pancreatic beta-cells. Islet transplantation is an effective therapy, but its …
destruction of pancreatic beta-cells. Islet transplantation is an effective therapy, but its …
[HTML][HTML] Non-invasive quantification of stem cell-derived islet graft size and composition
V Lithovius, S Lahdenpohja, H Ibrahim… - Diabetologia, 2024 - Springer
Aims/hypothesis Stem cell-derived islets (SC-islets) are being used as cell replacement
therapy for insulin-dependent diabetes. Non-invasive long-term monitoring methods for SC …
therapy for insulin-dependent diabetes. Non-invasive long-term monitoring methods for SC …
Innovations in bio-engineering and cell-based approaches to address immunological challenges in islet transplantation
BX Ho, AKK Teo, NHJ Ng - Frontiers in Immunology, 2024 - frontiersin.org
Human allogeneic pancreatic islet transplantation is a life-changing treatment for patients
with severe Type 1 Diabetes (T1D) who suffer from hypoglycemia unawareness and high …
with severe Type 1 Diabetes (T1D) who suffer from hypoglycemia unawareness and high …