Background SARS-CoV-2 enters cells by binding of its spike protein to angiotensin-
converting enzyme 2 (ACE2). Angiotensin-converting enzyme inhibitors (ACEIs) or …

Endometriosis (EM) is a chronic disease characterized by the presence and proliferation of
functional endometrial glands and stroma outside the uterine cavity. Ovaries and pelvic …

Background Hereditary angioedema (HAE) is a potentially fatal disorder resulting in
recurrent attacks of severe swelling. It may be associated with a genetic deficiency of …

Background Hereditary angioedema is characterized by recurrent and unpredictable
swellings that are disabling and potentially fatal. Selective inhibition of plasma prekallikrein …

Background Guidelines recommend effective on-demand therapy for all individuals with
hereditary angioedema. We aimed to assess the novel oral plasma kallikrein inhibitor …

To date the pathophysiology of COVID-19 remains unclear: this represents a factor
determining the current lack of effective treatments. In this paper, we hypothesized a …

Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation
proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation …

Abstract C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a
major negative regulator of several biological pathways, including the contact pathway of …

Appropriate activation of coagulation requires a balance between procoagulant and
anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis. A …

Background Hereditary angioedema (HAE) is a rare, life-threatening genetic disorder
characterized by recurrent episodes of subcutaneous or submucosal angioedema. The …