Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …

Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

During blood stage Plasmodium falciparum infection, merozoites invade uninfected
erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand …

Malaria is a major disease of humans caused by protozoan parasites from the genus
Plasmodium. It has a complex life cycle; however, asexual parasite infection within the blood …

More than a century after the discovery of Plasmodium spp. parasites, the pathogenesis of
severe malaria is still not well understood. The majority of malaria cases are caused by …

Background One of the criteria to objectively prioritize merozoite antigens for malaria
vaccine development is the demonstration that naturally acquired antibodies are associated …

The development of effective malaria vaccines and immune biomarkers of malaria is a high
priority for malaria control and elimination. Ags expressed by merozoites of Plasmodium …

Plasmodium falciparum is responsible for the most severe form of malaria disease in
humans, causing more than 1 million deaths each year. As an obligate intracellular parasite …

Invasion of erythrocytes is a prerequisite in the life history of the malaria parasite. Members
of the reticulocyte-binding homologue family (PfRh) have been implicated in the invasion …