[HTML][HTML] Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis

A Rani, J Barter, A Kumar, JA Stortz, MK Hollen… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Sepsis, defined as a dysregulated host immune response to infection, is a common and
dangerous clinical syndrome. The excessive host inflammatory response can induce …

Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats

F Lian, C Cao, F Deng, C Liu, Z Zhou - Cytokine, 2022 - Elsevier
Objective Postoperative cognitive dysfunction (POCD) affects 15–25% of surgical patients
and causes significant morbidity and mortality. This study aims to investigate the mechanism …

Stellate ganglion block improves postoperative cognitive dysfunction in aged rats by SIRT1-mediated white matter lesion repair

J Zhang, Y Liu, H Li, Y Hu, S Yu, Q Liu, Y Chen - Neurochemical Research, 2022 - Springer
Postoperative cognitive dysfunction (POCD) is a common complication of the central
nervous system after surgery, especially in elderly patients. Many factors can influence …

Microarray analysis identifies key differentially expressed circular RNAs in aged mice with postoperative cognitive dysfunction

YQ Wu, Q Liu, HB Wang, C Chen, H Huang… - Frontiers in Aging …, 2021 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients.
Circular RNAs (circRNAs) may contribute to neurodegenerative diseases. However, the role …

Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder

W Wu, Y Peng, J Zhou, X Zhang, L Cao, W Lin… - Frontiers in …, 2021 - frontiersin.org
Postoperative neurocognitive disorder (PND) is one of the most common postoperative
neurological complications in aged patients, characterized by mental disorder, anxiety …

Effects of miR‐190a‐3p on Sevoflurane‐induced postoperative cognitive dysfunction (POCD)

LL Guo, Y Wang, HY Wang, S Song… - Journal of Biochemical …, 2023 - Wiley Online Library
Postoperative cognitive dysfunction (POCD) is regularly observed in patients postsurgery
due to the usage of anesthetics, including Sevoflurane. Research has confirmed the …

Hepcidin regulates neuronal ferroptosis: A mechanism for postoperative cognitive dysfunction

H Shen, L Zhai, G Wang - Journal of biochemical and molecular …, 2022 - Wiley Online Library
Abstract Toll‐like receptor 4 (TLR4) is a signaling molecule responsible for the expression of
hepcidin (Hepc), while myeloid differentiation protein 2 (MD2) is one major accessory …

Construction and analysis of circular RNA-associated competing endogenous RNA network in the hippocampus of aged mice for the occurrence of postoperative …

M Zhang, Z Suo, Y Qu, Y Zheng, W Xu… - Frontiers in Aging …, 2023 - frontiersin.org
Circular RNAs are highly stable single-stranded circular RNAs and enriched in the brain.
Previous studies showed that circRNAs, as part of competing endogenous RNAs (ceRNAs) …

MiR-214-3p prevents the development of perioperative neurocognitive disorders in elderly rats

Y Wang, Y Chen, W Xiao, X Li, L Feng, Y Liu… - Current Medical …, 2022 - Springer
Objective This study aimed to identify microRNAs (miRNAs) involved in the development of
perioperative neurocognitive disorders (PND). Methods Plasma exosomal miRNA …

Research Progress on Exosomes and MicroRNAs in the Microenvironment of Postoperative Neurocognitive Disorders

Q Huang, Y Zhou, H He, S Lin, X Chen - Neurochemical Research, 2022 - Springer
Postoperative neurocognitive disorder (PND) is a disease that frequently develops in older
patients during the perioperative period. It seriously affects the quality of life of the affected …