Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Liquid–liquid phase separation has drawn attention as many neurodegeneration or cancer-
associated proteins are able to form liquid membraneless compartments (condensates) by …

Highlights•Intrinscially disordered proteins (IDPs) are abundant and involved in many
diseases.•Advances and challenges in drug design targeting IDPs are discussed.•Known …

Transcription factors (TFs) act as major oncodrivers in many cancers and are frequently
regarded as high-value therapeutic targets. The functionality of TFs relies on direct protein …

Intrinsically disordered proteins (IDPs) are associated with various diseases and have been
proposed as promising drug targets. However, conventional structure-based approaches …

Intrinsically disordered proteins (IDPs) do not have rigid 3D structures, showing changes in
their folding depending on the environment or ligands. Intrinsically disordered proteins are …

ABSTRACT Introduction: Intrinsically disordered proteins (IDPs) and regions (IDRs) lack
stable three-dimensional structure making drug discovery challenging. A validated …

Intrinsically disordered proteins (IDPs) are proteins that perform important biological
functions without well‐defined structures under physiological conditions. IDPs can form …

Intrinsically disordered proteins (IDP) are abundant in the human genome and have recently
emerged as major therapeutic targets for various diseases. Unlike traditional proteins that …

Intrinsically disordered proteins (IDPs) are over-represented in major disease pathways and
have attracted significant interest in understanding if and how they may be targeted using …