Physiologic alterations seen in obesity commonly impact the pharmacokinetics (PK) and
pharmacodynamics (PD) of antibiotics and may result in suboptimal dosing in this …

Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …

Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to
hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic …

Introduction: Identifying the optimized dosing regimen and algorithm is critical in the
development of antibiotics. Suboptimal regimens and inappropriate choice of drug give rise …

The scope of TDM is broadening from the traditional focus on prevention of toxicity, to
include optimization of antibiotic exposure thereby improving patient outcomes. However …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in …

Breakpoints are the values used by clinical microbiology laboratories to interpret the results
of antimicrobial susceptibility testing (AST) and classify isolates as susceptible or resistant …

Drug dosing in obese patients continues to be challenging due to a lack of high‐quality
evidence to guide dosing recommendations. We first published guidance for antibiotic …

The study objective was to evaluate meropenem population pharmacokinetics and
pharmacodynamics in nonobese, obese, and morbidly obese patients. Forty adult patients …

Purpose Pseudomonas aeruginosa is a commonly isolated nosocomial pathogen for which
treatment options are often limited for multidrug-resistant isolates. In addition to newer …