[HTML][HTML] Osteoarthritis: a narrative review of molecular approaches to disease management
Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …
[HTML][HTML] Molecular classification of knee osteoarthritis
Z Lv, YX Yang, J Li, Y Fei, H Guo, Z Sun, J Lu… - Frontiers in cell and …, 2021 - frontiersin.org
Knee osteoarthritis (KOA) is the most common form of joint degeneration with increasing
prevalence and incidence in recent decades. KOA is a molecular disorder characterized by …
prevalence and incidence in recent decades. KOA is a molecular disorder characterized by …
The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF‐1α to inhibit knee osteoarthritis‐induced ferroptosis
Z Guan, X Jin, Z Guan, S Liu, K Tao, L Luo - Aging Cell, 2023 - Wiley Online Library
Ferroptosis is an iron‐dependent cell death that has been found to aggravate the
progression of osteoarthritis (OA) and gut microbiota‐OA axis refers to the bidirectional …
progression of osteoarthritis (OA) and gut microbiota‐OA axis refers to the bidirectional …
Top-down fabricated microplates for prolonged, intra-articular matrix metalloproteinase 13 siRNA nanocarrier delivery to reduce post-traumatic osteoarthritis
Post-traumatic osteoarthritis (PTOA) associated with joint injury triggers a degenerative cycle
of matrix destruction and inflammatory signaling, leading to pain and loss of function. Here …
of matrix destruction and inflammatory signaling, leading to pain and loss of function. Here …
Targeted treatment for osteoarthritis: drugs and delivery system
L Mao, W Wu, M Wang, J Guo, H Li, S Zhang, J Xu… - Drug …, 2021 - Taylor & Francis
The management of osteoarthritis (OA) is a clinical challenge due to the particular avascular,
dense, and occluded tissue structure. Despite numerous clinical reports and animal studies …
dense, and occluded tissue structure. Despite numerous clinical reports and animal studies …
Exosomes derived from mesenchymal stem cells rescue cartilage injury in osteoarthritis through Ferroptosis by GOT1/CCR2 expression
S Peng, C Sun, C Lai, L Zhang - International Immunopharmacology, 2023 - Elsevier
Osteoarthritis is a prevalent joint disease that significantly affects the daily life of the elderly
and is one of the primary causes of disability in this population. This study aims to evaluate …
and is one of the primary causes of disability in this population. This study aims to evaluate …
Reconstruction for chronic ACL tears with or without anterolateral structure augmentation in patients at high risk for clinical failure: a randomized clinical trial
Background: The purpose of this trial was to determine whether anterior cruciate ligament
reconstruction (ACLR) with anterolateral structure augmentation (ALSA) would result in …
reconstruction (ACLR) with anterolateral structure augmentation (ALSA) would result in …
[HTML][HTML] Post-traumatic osteoarthritis progression is diminished by early mechanical unloading and anti-inflammatory treatment in mice
AW Hsia, EH Jbeily, ME Mendez… - Osteoarthritis and …, 2021 - Elsevier
Objective Post-traumatic osteoarthritis (PTOA) is a degenerative joint disease initiated by
injury. Early phase (0–7 days) treatments often include rest (unloading) and anti …
injury. Early phase (0–7 days) treatments often include rest (unloading) and anti …
[HTML][HTML] Patient-reported outcomes and factors associated with achieving the minimal clinically important difference after ACL reconstruction: results at a mean 7.7 …
BU Nwachukwu, SW Sullivan, RC Rauck… - JBJS Open …, 2021 - journals.lww.com
Background: Analyzing outcomes and the minimal clinically important difference (MCID)
after anterior cruciate ligament reconstruction (ACLR) is of increased interest in the …
after anterior cruciate ligament reconstruction (ACLR) is of increased interest in the …
[HTML][HTML] Finding the Goldilocks Zone of Mechanical Loading: A Comprehensive Review of Mechanical Loading in the Prevention and Treatment of Knee Osteoarthritis
In this review, we discuss the interaction of mechanical factors influencing knee
osteoarthritis (KOA) and post-traumatic osteoarthritis (PTOA) pathogenesis. Emphasizing the …
osteoarthritis (KOA) and post-traumatic osteoarthritis (PTOA) pathogenesis. Emphasizing the …