Mechanism-guided development of transition-metal-catalyzed C–N bond-forming reactions using dioxazolones as the versatile amidating source
Conspectus Catalytic reactions that construct carbon–nitrogen bonds are one of central
themes in both synthetic and medicinal chemistry since the obtainable nitrogen-containing …
themes in both synthetic and medicinal chemistry since the obtainable nitrogen-containing …
Catalytic enantioselective functionalizations of C–H bonds by chiral iridium complexes
The development of catalytic enantioselective transformations, enabling the construction of
complex molecular scaffolds from simple precursors, has been a long-standing challenge in …
complex molecular scaffolds from simple precursors, has been a long-standing challenge in …
Energy-transfer-induced [3+ 2] cycloadditions of N–N pyridinium ylides
Photocycloaddition is a powerful reaction to enable the conversion of alkenes into high-
value synthetic materials that are normally difficult to obtain under thermal conditions …
value synthetic materials that are normally difficult to obtain under thermal conditions …
[HTML][HTML] Podophyllotoxin and its derivatives: Potential anticancer agents of natural origin in cancer chemotherapy
S Motyka, K Jafernik, H Ekiert, J Sharifi-Rad… - Biomedicine & …, 2023 - Elsevier
The use of plant secondary metabolites has gained considerable attention among clinicians
in the prevention and treatment of cancer. A secondary metabolite isolated mainly from the …
in the prevention and treatment of cancer. A secondary metabolite isolated mainly from the …
[HTML][HTML] Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry
Nitrogen containing heterocycles are of immense research interest because they are often
found as naturally occurring bioactive compounds. The prominence of N-heterocycles …
found as naturally occurring bioactive compounds. The prominence of N-heterocycles …
Enantio- and diastereoselective construction of vicinal C(sp3) centres via nickel-catalysed hydroalkylation of alkenes
In drug discovery, the proportion of aliphatic carbons (C (sp 3)) and the presence of chiral
carbons in organic molecules are positively correlated to their chance of clinical success …
carbons in organic molecules are positively correlated to their chance of clinical success …
CO2-Promoted Reactions: An Emerging Concept for the Synthesis of Fine Chemicals and Pharmaceuticals
Carbon dioxide is a nontoxic and abundant chemical and has been widely used as a C1
building block for the synthesis of highly important chemicals. This greenhouse gas also has …
building block for the synthesis of highly important chemicals. This greenhouse gas also has …
Direct α-alkylation of primary aliphatic amines enabled by CO2 and electrostatics
Primary aliphatic amines are important building blocks in organic synthesis due to the
presence of a synthetically versatile NH2 group. N-functionalization of primary amines is …
presence of a synthetically versatile NH2 group. N-functionalization of primary amines is …
Asymmetric formation of γ-lactams via C–H amidation enabled by chiral hydrogen-bond-donor catalysts
Chiral γ-lactams are effective structural motifs found in numerous pharmaceutical agents.
Despite their importance, current approaches mostly necessitate laborious synthetic steps …
Despite their importance, current approaches mostly necessitate laborious synthetic steps …
[HTML][HTML] Photoredox-catalyzed diastereoselective dearomative prenylation and reverse-prenylation of electron-deficient indole derivatives
X Chang, F Zhang, S Zhu, Z Yang, X Feng… - Nature …, 2023 - nature.com
Prenylated and reverse-prenylated indolines are privileged scaffolds in numerous naturally
occurring indole alkaloids with a broad spectrum of important biological properties …
occurring indole alkaloids with a broad spectrum of important biological properties …