Although nanomedicines can passively target tumor through the enhanced permeability and
retention (EPR) effect, their distribution and retention are limited by complex tumor …

A two-pronged concept combining photodynamic therapy (PDT) and epithelial–
mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to …

Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) holds
great promise for deep tissue visualization. Development of novel clinical translatable NIR‐II …

After an osteosarcoma excision, recurrence, large bone defects, and soft tissue injury are
significant challenges for clinicians. Conventional treatment by implanting bone replacement …

Phototherapy and immunotherapy in combination is regarded as the ideal therapeutic
modality to treat both primary and metastatic tumors. Immunotherapy uses different …

Postmenopausal osteoporosis (PMOP) is a prevalent skeletal disorder associated with
menopause-related estrogen withdrawal. PMOP is characterized by low bone mass …

Bone diseases including osteoarthritis, osteoporosis, and bone tumors are becoming severe
threats to public health. Bone-targeted biomaterials-based strategies could improve …

Bone diseases, such as bone cancer, bone infection and osteoporosis, constitute a major
issue for modern societies as a consequence of their progressive ageing. Even though …

Recently, bone marrow endothelial cells (BMECs) were found to play an important role in
regulating bone homeostasis. However, few studies utilized BMECs to treat bone metabolic …

Owing to the high density of bone tissue and the complex and highly hierarchical structure,
drugs used for the treatment of bone-related diseases are often not effectively concentrated …