Red blood cells (RBCs) constitute a unique drug delivery system as a biologic or hybrid
carrier capable of greatly enhancing pharmacokinetics, altering pharmacodynamics (for …

In vitro studies of vascular physiology have traditionally relied on cultures of endothelial
cells, smooth muscle cells, and pericytes grown on centimeter-scale plates, filters, and flow …

Hematocrit and vessel wall shear rate are important factors in the transport and subsequent
adherence of platelets to vessel wall subendothelium. When mass transport theory is …

Normal hemostasis is initiated by damage of the vessel wall with exposure of subendothelial
structures to flowing blood and results in the formation of a solid hemostatic plug. The first …

Conventional risk factors predict only about 30–50% of incidental cases in cardiovascular
diseases, which are still the leading cause of death in western societies. During the last …

Hemorrheology, the science of the flow behavior of blood, has become increasingly
important in clinical situations. The rheology of blood is dependent on its viscosity, which in …

The rigidity of red blood cells (RBCs) plays an important role in whole blood viscosity and is
correlated with several cardiovascular diseases. Two chemical agents that are commonly …

The study of blood ex vivo can occur in closed or open systems, with or without flow.
Microfluidic devices, which constrain fluids to a small (typically submillimeter) scale, facilitate …

A high-fidelity computational model using a 3D immersed boundary method is used to study
platelet dynamics in whole blood. We focus on the 3D effects of the platelet-red blood cell …

Red blood cells (RBCs) are innate carriers that can also be engineered to improve the
pharmacokinetics and pharmacodynamics of many drugs, particularly biotherapeutics …