Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

The pathological mechanisms and potential therapeutic drugs for myocardial ischemia reperfusion injury

S Zhang, F Yan, F Luan, Y Chai, N Li, YW Wang… - Phytomedicine, 2024 - Elsevier
Background Cardiovascular disease is the main cause of death and disability, with
myocardial ischemia being the predominant type that poses a significant threat to humans …

[HTML][HTML] Ferroptosis preceded the onset of oxidative stress under acute ammonia exposure and quercetin relieved ammonia-induced ferroptosis of yellow catfish …

X Long, K He, M Zhang, H Jiang, X Dong, C Wang… - Aquaculture …, 2023 - Elsevier
Ammonia is the most common pollutant and stressor in the aquaculture environment and
can cause massive fish mortality. Its toxicity in fish is mainly related to the generation of …

Ferroptosis targeting natural compounds as a promising approach for developing potent liver cancer agents

P Pandey, D Elsori, R Kumar, S Lakhanpal… - Frontiers in …, 2024 - frontiersin.org
Liver cancer is the second leading cause of cancer-related death worldwide. However,
treatment options, including surgical resection, transplantation, and molecular drug …

Putative Molecular Mechanisms Underpinning the Inverse Roles of Mitochondrial Respiration and Heme Function in Lung Cancer and Alzheimer's Disease

A Afsar, L Zhang - Biology, 2024 - mdpi.com
Simple Summary Well-balanced mitochondrial respiration and function are crucial for
human health. Altered mitochondrial function underlies the pathogenesis of both Alzheimer's …

Targeting the Ferroptosis and Endoplasmic Reticulum Stress Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion Injury

W Jiang, Z Yan, X Zheng, S Huang, Y Hu… - Cell Biochemistry and …, 2024 - Springer
Ferroptosis and endoplasmic reticulum stress (ERS) are common events in the process of
myocardial ischemia/reperfusion injury (IRI). The suppression of chromobox7 (CBX7) has …

Effect of human heart valve-derived ECM and NP/PCL electrospun nanofibrous sheet on mice bone marrow mononuclear cells and cardiac repair

Y Chen, Z Huang, C Ji, JH Shi - Heliyon, 2024 - cell.com
Background Biomaterials can improve cardiac repair combined with transplantation of bone
marrow mononuclear cells (BMMNCs). In this study, we compared the phenotype and …

SGLT2 抑制剂在急性心肌梗死中的保护作用

陈诚, 张钲, 彭瑜, 牛小伟, 何世林, 窦文朝 - 临床心血管病杂志, 2024 - lcxxg.whuhzzs.com
钠-葡萄糖协同转运蛋白2 (SGLT2) 抑制剂是一种新型的口服降糖药, 越来越多的临床研究显示
SGLT2 抑制剂可以改善糖尿病或非糖尿病患者的心血管预后, 显示出SGLT2 抑制剂的多效性 …

ATF3/EGR1 regulates myocardial ischemia/reperfusion injury induced autophagy and inflammation in cardiomyocytes

L Li, G Fu, C Liu, Y Liu - Cellular and Molecular Biology, 2024 - cellmolbiol.org
Myocardial ischemia/reperfusion injury (MIRI) is an irreversible adverse event during the
management of coronary heart disease that lacks effective controls. The underlying …

Piroptózis, PANoptózis és ferroptózis a szív iszkémia/reperfúziós károsodásában

M Pipicz, V Demján, C Csonka, TB Csont - Cardiologia Hungarica, 2023 - real.mtak.hu
Az intenzív kutatások ellenére továbbra sem rendelkezünk olyan kardioprotektív
gyógyszerekkel, amelyek a szív iszkémia/reperfúziós (I/R) károsodásával járó …