[HTML][HTML] Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

U Anand, A Dey, AKS Chandel, R Sanyal, A Mishra… - Genes & …, 2023 - Elsevier
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

Cisplatin in cancer treatment

AMP Romani - Biochemical pharmacology, 2022 - Elsevier
Cisplatin is a widely used chemotherapy agent in the treatment of various forms of
carcinomas and sarcomas. Its effectiveness in delaying negative outcome in cancer patients …

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

AJ Abadi, S Mirzaei, MK Mahabady… - Phytotherapy …, 2022 - Wiley Online Library
Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor
activity, which has shown significant efficacy in pre‐clinical and clinical studies. Curcumin …

miRNAs as potential game-changers in bone diseases: Future medicinal and clinical Uses

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

Cisplatin in ovarian cancer treatment—known limitations in therapy force new solutions

A Zoń, I Bednarek - International journal of molecular sciences, 2023 - mdpi.com
Cisplatin is one of the most commonly used anticancer drugs worldwide. It is mainly used in
the treatment of ovarian cancer, but also used in testicular, bladder and lung cancers. The …

Unraveling and overcoming platinum drug‐resistant cancer tumors with DNA nanostructures

Y Yu, L Zhang, Z Qin, J Karges… - Advanced Functional …, 2023 - Wiley Online Library
Abstract All chemotherapeutic treatments worldwide (> 50%) use platinum‐based
compounds. Despite their clinical success, an increasing number of platinum drug‐resistant …

Tumor microenvironment-triggered intratumoral in-situ biosynthesis of inorganic nanomaterials for precise tumor diagnostics

X Zhang, Q Zhao, J Yang, T Wang, F Chen… - Coordination Chemistry …, 2023 - Elsevier
The severe side effects and low bioavailability of conventional chemotherapeutic drugs are
the major problems that current clinical cancer treatments suffer from. In recent years, tumor …

[HTML][HTML] Metal-and metalloid-based compounds to target and reverse cancer multidrug resistance

A Valente, A Podolski-Renić, I Poetsch… - Drug Resistance …, 2021 - Elsevier
Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …

Elucidating role of reactive oxygen species (ROS) in cisplatin chemotherapy: a focus on molecular pathways and possible therapeutic strategies

S Mirzaei, K Hushmandi, A Zabolian, H Saleki… - Molecules, 2021 - mdpi.com
The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective
treatment of cancer patients, it is of great importance to reveal the molecular pathways and …

NK cell-derived exosomes enhance the anti-tumor effects against ovarian cancer by delivering cisplatin and reactivating NK cell functions

H Luo, Y Zhou, J Zhang, Y Zhang, S Long… - Frontiers in …, 2023 - frontiersin.org
Exosomes are membranous vesicles actively secreted by almost all cells and they deliver
certain intracellular molecules, including nucleic acids, proteins, and lipids, to target cells …