Kidney transplantation is the treatment of choice for patients with kidney failure. Compared
to dialysis therapy, it provides better quality of life and confers significant survival advantage …

Cold ischemia-reperfusion injury (IRI) is an inevitable and unresolved problem that poses a
great challenge in solid organ transplantation (SOT). It represents a major factor that …

Introduction Cold ischemia-reperfusion injury (IRI) is an inevitable event that increases post-
transplant complications. We have previously demonstrated that supplementation of …

Introduction Alpha-lipoic acid (ALA) is a licensed drug for the treatment of diabetic
neuropathy. We recently reported that it also improves diabetic cardiomyopathy (DCM) in …

Introduction We previously reported that alpha-lipoic acid (ALA) supplementation protects
against progression of diabetic kidney disease (DKD). In this study, we aim to investigate …

Simple Summary In this study, we explore for the first time an innovative tool for organ
preservation aimed to preventing ischemia reperfusion injury (IRI) in marginal kidneys from …

The global donor kidney shortage crisis has necessitated the use of suboptimal kidneys from
donors-after-cardiac-death (DCD). Using an ex vivo porcine model of DCD kidney …

Background Diabetes-induced liver injury is a complication of diabetes mellitus of which
there are no approved drugs for effective treatment or prevention. This study investigates …

Ischemia–reperfusion injury (IRI) is a critical pathological condition in which cell death plays
a major contributory role, and negatively impacts post-transplant outcomes. At the cellular …

We previously reported that normothermic ex vivo kidney perfusion (NEVKP) is superior in
terms of organ protection compared to static cold storage (SCS), which is still the standard …