Background Despite multiple revisions of targets and timelines in polio eradication plans
since 1988, including changes in supplemental immunization activities (SIAs) that increase …

Background Polio antiviral drugs (PAVDs) may provide a critical tool in the eradication
endgame by stopping poliovirus infections in immunodeficient individuals who may not clear …

Background Multiple vaccine options are available for polio prevention and risk
management. Integrated global risk, economic, and poliovirus transmission modeling …

Background: The polio eradication endgame continues to increase in complexity. With polio
cases caused by wild poliovirus type 1 and circulating vaccine-derived polioviruses of all …

Abstract The Global Polio Eradication Initiative (GPEI) faces substantial challenges with
managing outbreaks of serotype 2 circulating vaccine-derived polioviruses (cVDPV2s) in …

Despite a strong global commitment, polio eradication efforts continue now more than 30
years after the 1988 World Health Assembly resolution that established the Global Polio …

Delays in achieving polio eradication have led to ongoing risks of poliovirus importations
that may cause outbreaks in polio-free countries. Because of the low, but non-zero risk of …

Achieving the eradication of poliomyelitis remains an elusive goal. More than 6 years after
the globallycoordinated cessation of all use of type 2 oral poliovirus vaccines (OPV2) in …

Objectives The emergence of human pathogens with pandemic potential motivates rapid
vaccine development. We explore the role of vaccines in control and eradication of a novel …

The oral poliovirus vaccines (OPVs) are one of the most effective disease eradication tools
in public health. However, the OPV strains are genetically unstable and can cause …