Assessing pharmacokinetic correlates of escitalopram-related adverse drug reactions
M Kuzin, E Haen, N Kuzo, K Endres… - Therapeutic Drug …, 2024 - journals.lww.com
Background: To assess the pharmacokinetic correlates of reported adverse drug reactions
(ADRs) under antidepressant treatment with escitalopram (ESC) using a large therapeutic …
(ADRs) under antidepressant treatment with escitalopram (ESC) using a large therapeutic …
Novel Identification of Cysteinyl Derivatives of Toxic Clozapine Nitrenium Ions and the Effect of Valproic Acid on Metabolite Formation: A Study Using Reprocessed …
BM Wollmann, AG Haugen, RL Smith… - Therapeutic Drug …, 2024 - journals.lww.com
Background: Clozapine (CLZ) use is hampered by the risk of granulocyte toxicity, which is
associated with the formation of nitrenium ions and the concurrent use of valproic acid …
associated with the formation of nitrenium ions and the concurrent use of valproic acid …
Changes in psychotropic drug blood levels after SARS-CoV-2 vaccination: a two-center cohort study
M Kuzin, F Gardin, M Götschi… - Therapeutic Drug …, 2023 - journals.lww.com
Background: Limited evidence from case reports suggests that coronavirus disease 2019
(COVID-19) vaccination may interact with the treatment outcomes of psychiatric medications …
(COVID-19) vaccination may interact with the treatment outcomes of psychiatric medications …
Establishing and Extending the Use of Therapeutic Drug Monitoring in Neuropsychopharmacology
G Schoretsanitis - Therapeutic Drug Monitoring, 2024 - journals.lww.com
Compared with that in previous decades, a prolonged phase of marked stagnation in the
development of novel neuropsychopharmacological agents has recently been observed. 1 …
development of novel neuropsychopharmacological agents has recently been observed. 1 …
Elevation of Alpha-1 Acid Glycoprotein During Acute Infection Increases Clozapine Levels Without Signs of Intoxication
M Spangemacher, XM Hart, E Saalfrank… - Journal of Clinical …, 2024 - journals.lww.com
Clozapine (CLZ) is a highly effective antipsychotic in psychiatry, 1 making it particularly
relevant for patients with treatment-resistant schizophrenia. 2 However, CLZ toxicity poses …
relevant for patients with treatment-resistant schizophrenia. 2 However, CLZ toxicity poses …
Differential expression of Cytochrome P450 1A2 in simple fatty liver and steatohepatitis
A Kawashima, N Uramaru, T Mikuma… - Fundamental …, 2023 - jstage.jst.go.jp
Clarifying the cytochrome P450s (CYPs) changes in non-alcoholic fatty liver disease
(NAFLD) is important for optimizing drug therapy. This study compared the expression of …
(NAFLD) is important for optimizing drug therapy. This study compared the expression of …
A Short Turnaround of Clozapine Blood Level Results Within 6 hours is Essential for Effective Management of Severely Ill Persons with Treatment-Resistant …
PD Vincent, A Lesage, P Lalonde, O Lipp… - Therapeutic Drug …, 2022 - journals.lww.com
1. Tolerance of supratherapeutic range in case of infections. Inflammation may lead to
elevated clozapine levels and increase its volume of distribution. 2 Elevated clozapine …
elevated clozapine levels and increase its volume of distribution. 2 Elevated clozapine …