Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …

Degenerative retinal disorders are a diverse family of diseases commonly leading to
irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent …

The current optogenetic toolkit lacks a robust single-component Ca2+-selective ion channel
tailored for remote control of Ca2+ signaling in mammals. Existing tools are either derived …

Regulated cell death (RCD) controls the removal of dispensable, infected or malignant cells,
and is thus essential for development, homeostasis and immunity of multicellular organisms …

Astrocytes are sensitive to ongoing neuronal/network activities and, accordingly, regulate
neuronal functions (synaptic transmission, synaptic plasticity, behavior, etc.) by the context …

Channelrhodopsins are light-gated ion channels used to control excitability of designated
cells in large networks with high spatiotemporal resolution. While ChRs selective for H+ …

The human genome encodes 850 G protein-coupled receptors (GPCRs), half of which are
considered potential drug targets. GPCRs transduce extracellular stimuli into a plethora of …

G protein-coupled receptors (GPCRs) regulate a wide range of physiological and
pathophysiological cellular processes, thus it is important to understand how GPCRs are …

Astrocytes have been in the limelight of active research for about 3 decades now. Over this
period, ideas about their function and role in the nervous system have evolved from simple …

Memory processes rely on a molecular signaling system that balances the interplay between
positive and negative modulators. Recent research has focused on identifying memory …