Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia

S Peixoto da Silva, JMO Santos… - Journal of cachexia …, 2020 - Wiley Online Library
Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal
muscle mass, along with adipose tissue wasting, systemic inflammation and other metabolic …

[HTML][HTML] Physical exercise-induced myokines and muscle-adipose tissue crosstalk: a review of current knowledge and the implications for health and metabolic …

LG Leal, MA Lopes, ML Batista Jr - Frontiers in physiology, 2018 - frontiersin.org
Physical exercise has beneficial effects on metabolic diseases, and a combined therapeutic
regimen of regular exercise and pharmaceutical treatment is often recommended for their …

Cancer cachexia: understanding the molecular basis

JM Argilés, S Busquets, B Stemmler… - Nature Reviews …, 2014 - nature.com
Cancer cachexia is a devastating, multifactorial and often irreversible syndrome that affects
around 50–80% of cancer patients, depending on the tumour type, and that leads to …

Inter-tissue communication in cancer cachexia

JM Argilés, B Stemmler, FJ López-Soriano… - Nature Reviews …, 2019 - nature.com
Cachexia is a systemic condition that occurs during many neoplastic diseases, such as
cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by …

[HTML][HTML] Molecular mechanisms of inflammation in sarcopenia: diagnosis and therapeutic update

GE Jimenez-Gutierrez, LE Martínez-Gómez… - Cells, 2022 - mdpi.com
Sarcopenia is generally an age-related condition that directly impacts the quality of life. It is
also related to chronic diseases such as metabolic dysfunction associated with diabetes and …

[HTML][HTML] Myokines and resistance training: a narrative review

BEM Zunner, NB Wachsmuth, ML Eckstein… - International journal of …, 2022 - mdpi.com
In the last few years, the muscular system has gained attention due to the discovery of the
muscle-secretome and its high potency for retaining or regaining health. These cytokines …

[HTML][HTML] Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle

T Shan, X Liang, P Bi, S Kuang - The FASEB Journal, 2013 - ncbi.nlm.nih.gov
Myostatin (Mstn) is predominantly expressed in skeletal muscles and plays important roles
in regulating muscle growth and development, as well as fat deposition. Mstn-knockout …

Inter‐organ communication: a gatekeeper for metabolic health

J Castillo‐Armengol, L Fajas, IC López‐Mejía - EMBO reports, 2019 - embopress.org
Multidirectional interactions between metabolic organs in the periphery and the central
nervous system have evolved concomitantly with multicellular organisms to maintain whole …

Advances in research on pharmacotherapy of sarcopenia

Y Feike, L Zhijie, C Wei - Aging Medicine, 2021 - Wiley Online Library
Sarcopenia is a comprehensive degenerative disease with the progressive loss of skeletal
muscle mass with age, accompanied by the loss of muscle strength and muscle dysfunction …

[HTML][HTML] Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders

RC Smith, BK Lin - Current opinion in supportive and palliative …, 2013 - journals.lww.com
Myostatin inhibitors as therapies for muscle wasting associa... : Current Opinion in Supportive
and Palliative Care Myostatin inhibitors as therapies for muscle wasting associated with cancer …