Evolution of the human pathogenic lifestyle in fungi

A Rokas - Nature Microbiology, 2022 - nature.com
Fungal pathogens cause more than a billion human infections every year, resulting in more
than 1.6 million deaths annually. Understanding the natural history and evolutionary ecology …

[HTML][HTML] The impact of carbon and nitrogen catabolite repression in microorganisms

A Nair, SJ Sarma - Microbiological Research, 2021 - Elsevier
Organisms have cellular machinery that is focused on optimum utilization of resources to
maximize growth and survival depending on various environmental and developmental …

Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection

AE Barber, T Sae-Ong, K Kang, B Seelbinder, J Li… - Nature …, 2021 - nature.com
Aspergillus fumigatus is an environmental saprobe and opportunistic human fungal
pathogen. Despite an estimated annual occurrence of more than 300,000 cases of invasive …

The pan-genome of Aspergillus fumigatus provides a high-resolution view of its population structure revealing high levels of lineage-specific diversity driven by …

LA Lofgren, BS Ross, RA Cramer, JE Stajich - PLoS Biology, 2022 - journals.plos.org
Aspergillus fumigatus is a deadly agent of human fungal disease where virulence
heterogeneity is thought to be at least partially structured by genetic variation between …

On the lineage of Aspergillus fumigatus isolates in common laboratory use

M Bertuzzi, N Van Rhijn, S Krappmann… - Medical …, 2021 - academic.oup.com
The origin of isolates routinely used by the community of Aspergillus fumigatus researchers
is periodically a matter of intense discussion at our centre, as the construction of …

Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence Across Aspergillus Species

JL Steenwyk, ME Mead, SL Knowles, HA Raja… - Genetics, 2020 - academic.oup.com
Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of
Virulence Across Aspergillus Species | Genetics | Oxford Academic Skip to Main Content …

Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates of Aspergillus fumigatus

JL Steenwyk, ME Mead, PA de Castro… - Microbiology …, 2021 - Am Soc Microbiol
The ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), first described in …

Pathogenic allodiploid hybrids of Aspergillus fungi

JL Steenwyk, AL Lind, LNA Ries, TF Dos Reis, LP Silva… - Current Biology, 2020 - cell.com
Interspecific hybridization substantially alters genotypes and phenotypes and can give rise
to new lineages. Hybrid isolates that differ from their parental species in infection-relevant …

Genomic and Phenotypic Heterogeneity of Clinical Isolates of the Human Pathogens Aspergillus fumigatus, Aspergillus lentulus, and Aspergillus fumigatiaffinis

RAC Dos Santos, JL Steenwyk… - Frontiers in …, 2020 - frontiersin.org
Fungal pathogens are a global threat to human health. For example, fungi from the genus
Aspergillus cause a spectrum of diseases collectively known as aspergillosis. Most of the> …

Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor CreA

LJ de Assis, LP Silva, O Bayram, P Dowling… - MBio, 2021 - Am Soc Microbiol
Filamentous fungi of the genus Aspergillus are of particular interest for biotechnological
applications due to their natural capacity to secrete carbohydrate-active enzymes (CAZy) …