Extramedullary (EM) disease in patients with acute myeloid leukemia (AML) is a known
phenomenon. Since the prevalence of EM AML has so far only been clinically determined …

FLT3-ITD mutations are detected in approximately 25% of newly diagnosed adult acute
myeloid leukemia (AML) patients and confer an adverse prognosis. The FLT3-ITD allelic …

Purpose The College of American Pathologists (CAP) and the American Society of
Hematology (ASH) developed an evidence-based guideline on the initial diagnostic work-up …

HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) is a long non-coding RNA (lncRNA)
that is highly specific for maturing myeloid cells. Dysregulation of HOTAIRM1 has been …

Acute myeloid leukemia (AML) is a highly aggressive hematological malignancy with
complex heterogenous genetic and biological nature. Thus, prognostic prediction and …

Myelodysplastic syndromes (MDS) are a group of clonal hematological disease with high
risk of progression to AML. Accurate risk stratification is of importance for the proper …

The aim of this study was to evaluate the prognostic impact of FLT3-ITD in core-binding
factor acute myeloid leukemia (CBFAML) in an international, multicenter survey of 97 …

We categorize the resistance into BCR–ABL-dependent and BCR–ABL-independent
subgroups to further describe the complex molecular pathways which can potentially serve …

Simple Summary The resistance of neoplastic cells to multiple drugs is a serious problem in
cancer chemotherapy. The molecular causes of multidrug resistance in cancer are largely …

Cytarabine-anthracycline based intensive induction chemotherapy (IC) remains the
standard of care for remission induction among fit patients with newly diagnosed acute …