Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

Recent discoveries implicate the classical complement cascade in normal brain
development and in disease. Complement proteins C1q, C3, and C4 participate in synapse …

Systemic lupus erythematosus (SLE) is a severe chronic systemic autoimmune disease
caused by complicated interactions among genetic, epigenetic, and immunological factors …

Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by
autoantibody deposition in tissues such as kidney, skin and lungs. Notably, up to 75% of …

Lymph nodes (LNs), where immune responses are initiated, are organized into distinctive
compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by …

Plasma cells (PCs) are responsible for the production of protective antibodies against
infectious agents but they also produce pathogenic antibodies in autoimmune diseases …

Germinal centers (GCs) are the primary sites of clonal B cell expansion and affinity
maturation, directing the production of high-affinity antibodies. This response is a central …

Objective We investigated the mechanistic and pharmacological properties of anifrolumab, a
fully human, effector-null, anti-type I interferon (IFN) alpha receptor 1 (IFNAR1) monoclonal …

Lymphoid organs guarantee productive immune cell interactions through the establishment
of distinct microenvironmental niches that are built by fibroblastic reticular cells (FRC). These …

Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of
autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and …