Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

Transforming growth factor‐β (TGF‐β) superfamily signaling via their cognate receptors is
frequently modified by TGF‐β superfamily co‐receptors. Signaling through SMAD‐mediated …

The progress of genetic engineering in the 1970s brought about a paradigm shift in genome
editing technology. The clustered regularly interspaced short palindromic repeats/CRISPR …

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy owing to
relapse caused by resistance to chemotherapy. We previously reported that cluster of …

In nasopharyngeal carcinoma (NPC), the TGF-β/Smad pathway genes are altered with
inactive TGF-β signal, but the mechanisms remain unclear. RNA-sequencing results showed …

Metastasis is the leading cause of death in lung adenocarcinomas. Identifying potential
prognostic biomarkers and exploiting regulatory mechanisms could improve the diagnosis …

The CRISPR/Cas9 system enables a versatile set of genomes editing and genetic-based
disease modeling tools due to its high specificity, efficiency, and accessible design and …

Drug resistance is a considerable obstacle to gastric cancer (GC) treatment. The current
work aimed to elucidate the functional mechanism of CD109 in 5‐fluorouracil (5‐FU) …

Simple Summary Squamous cell carcinoma is a type of cancer resulting from cancer of the
squamous cells that line some organs of the body such as the skin, lungs, and vulva. It is …

Background The signal transducer and activator of transcription (STAT) protein family, a
group of seven members (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6) …