[HTML][HTML] Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity
Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …
membranes, and regulate energy metabolism. Questions remain as to which lipid species …
mTOR signalling and cellular metabolism are mutual determinants in cancer
D Mossmann, S Park, MN Hall - Nature Reviews Cancer, 2018 - nature.com
Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR,
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …
[HTML][HTML] mTOR as a central regulator of lifespan and aging
The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …
Lipid metabolism in cancer progression and therapeutic strategies
Y Fu, T Zou, X Shen, PJ Nelson, J Li, C Wu, J Yang… - MedComm, 2021 - Wiley Online Library
Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …
Emerging roles of lipid metabolism in cancer metastasis
X Luo, C Cheng, Z Tan, N Li, M Tang, L Yang, Y Cao - Molecular cancer, 2017 - Springer
Cancer cells frequently display fundamentally altered cellular metabolism, which provides
the biochemical foundation and directly contributes to tumorigenicity and malignancy …
the biochemical foundation and directly contributes to tumorigenicity and malignancy …
The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions
L Secomandi, M Borghesan, M Velarde… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …
quality as well as uterine and placental dysfunctions. These changes lead to infertility …
[HTML][HTML] Metformin: from mechanisms of action to therapies
Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …
Targeting the translation machinery in cancer
Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …
tumour suppressors affect the translation machinery, making aberrant translation a …
K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria
CJ Groß, R Mishra, KS Schneider, G Médard… - Immunity, 2016 - cell.com
Imiquimod is a small-molecule ligand of Toll-like receptor-7 (TLR7) that is licensed for the
treatment of viral infections and cancers of the skin. Imiquimod has TLR7-independent …
treatment of viral infections and cancers of the skin. Imiquimod has TLR7-independent …
Metformin—mode of action and clinical implications for diabetes and cancer
I Pernicova, M Korbonits - Nature Reviews Endocrinology, 2014 - nature.com
Metformin has been the mainstay of therapy for diabetes mellitus for many years; however,
the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed …
the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed …