Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR,
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

Cancer cells frequently display fundamentally altered cellular metabolism, which provides
the biochemical foundation and directly contributes to tumorigenicity and malignancy …

BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

Imiquimod is a small-molecule ligand of Toll-like receptor-7 (TLR7) that is licensed for the
treatment of viral infections and cancers of the skin. Imiquimod has TLR7-independent …

Metformin has been the mainstay of therapy for diabetes mellitus for many years; however,
the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed …