Melarsoprol and pentamidine represent the two main classes of drugs, the arsenicals and
diamidines, historically used to treat the diseases caused by African trypanosomes: sleeping …

Despite the many decades of use of most of the current trypanocides, we know little of their
mode of action. This may in part be because most of these will act on multiple targets once …

Human African trypanosomiasis (HAT, or sleeping sickness) is a protozoan parasitic
infection caused by Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense …

The natural curcuminoids curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin
(3) have been chemically modified to give 46 analogs and 8 pairs of 1: 1 mixture of …

Millions of people in the developing world are affected by diseases caused by the
kinetoplastid parasites: the leishmaniases, African trypanosomiasis, and Chagas disease. In …

Tsetse flies (Glossina spp.), vectors of African trypanosomes, are distinguished by their
specialized reproductive biology, defined by adenotrophic viviparity (maternal nourishment …

Treatment of many infectious diseases is under threat from drug resistance. Understanding
the mechanisms of resistance is as high a priority as the development of new drugs. We …

Following a period characterized by severe epidemics of sleeping sickness, restoration of
effective control and surveillance systems has raised the question of eliminating the disease …

The aromatic diamidine pentamidine has long been used to treat early-stage human African
trypanosomiasis (HAT). Two analogs of pentamidine, DB75 and DB820, have been shown …

Background Trypanosoma brucei is the etiological agent of Human African
Trypanosomiasis, an endemic parasitic disease of sub-Saharan Africa. TbCatB and …