Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis

E Thijssen, A Van Caam, PM Van Der Kraan - Rheumatology, 2015 - academic.oup.com
OA is a degenerative joint disease characterized by articular cartilage degradation,
osteophyte formation, synovitis, and subchondral bone sclerosis. One of OAs main risk …

Associations between adipokines in arthritic disease and implications for obesity

IJ MᵃᶜDonald, SC Liu, CC Huang, SJ Kuo… - International journal of …, 2019 - mdpi.com
Secretion from adipose tissue of adipokines or adipocytokines, comprising of bioactive
peptides or proteins, immune molecules and inflammatory mediators, exert critical roles in …

Evaluating the performance of 3D-printed PLA reinforced with date pit particles for its suitability as an acetabular liner in artificial hip joints

A Fouly, IA Alnaser, AK Assaifan, HS Abdo - Polymers, 2022 - mdpi.com
Off-the-shelf hip joints are considered essential parts in rehabilitation medicine that can help
the disabled. However, the failure of the materials used in such joints can cause individual …

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta‑analysis

GH Cui, YY Wang, CJ Li… - Experimental and …, 2016 - spandidos-publications.com
To assess the clinical efficacy and safety of mesenchymal stem cell (MSC) treatment for
osteoarthritis of the knee (KOA), a systematic electronic literature search was performed on …

Obesity, exercise and orthopedic disease

CW Frye, JW Shmalberg… - Veterinary Clinics: Small …, 2016 - vetsmall.theclinics.com
Osteoarthritis, or degenerative joint disease, is characterized by a complex progressive
imbalance between cartilage production and degradation. The inciting biochemical cause of …

[HTML][HTML] Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis

G Ruan, J Xu, K Wang, J Wu, Q Zhu, J Ren… - Osteoarthritis and …, 2018 - Elsevier
Objective To investigate cross-sectional associations between serum level of Matrix
metalloproteinase (MMP) 13 and knee structural measures and circulating inflammatory …

An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis

C Tu, J He, B Wu, W Wang, Z Li - Cytokine, 2019 - Elsevier
Osteoarthritis is the most prevalent form of aging-related joint diseases, and its etiology is
still not fully understood. Obesity has been recognized as one of the most significant and …

TNF‑α increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate‑induced …

H Li, S Xie, Y Qi, H Li, R Zhang… - Experimental and …, 2018 - spandidos-publications.com
Osteoarthritis is a degenerative disease that often causes patients to experience joint pain
and deformity. It has been demonstrated that tumor necrosis factor (TNF)‑α is associated …

Maslinic acid prevents IL‐1β‐induced inflammatory response in osteoarthritis via PI3K/AKT/NF‐κB pathways

YL Chen, DY Yan, CY Wu, JW Xuan… - Journal of Cellular …, 2021 - Wiley Online Library
Osteoarthritis (OA) is a degenerative joint disease characterized by destruction of articular
cartilage. The inflammatory response is the most important factor affecting the disease …

Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P …

D Kouroupis, AC Bowles, MA Willman… - Scientific reports, 2019 - nature.com
The infrapatellar fat pad (IFP) serves as a reservoir of Mesenchymal Stem Cells (MSC), and
with adjacent synovium plays key roles in joint disease including the production of …