The human liver is usually perceived as a non-immunological organ engaged primarily in
metabolic, nutrient storage and detoxification activities. However, we now know that the …

The hepatic immune system is constantly exposed to a massive load of harmless dietary and
commensal antigens, to which it must remain tolerant. Immune tolerance in the liver is …

Colorectal cancer is the third most common malignancy worldwide, with 1.3 million new
cases annually. Metastasis to the liver is a leading cause of mortality in these patients. In …

Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

Because of its location and function, the liver is continuously exposed to a large antigenic
load that includes pathogens, toxins, tumor cells and harmless dietary antigens. The range …

The human liver contains significant numbers of T cells, NK cells, and lymphocytes that
coexpress T and NK cell receptors. To evaluate their functional activities, we have compared …

In the past year, a subset of natural killer cells designated 'A-NK cells' has been
characterized. These immune cells appear to be able to enter solid tissues, migrate to sites …

Adaptive immunity has traditionally been considered a unique feature of vertebrate
physiology. Unlike innate immune responses, which remain essentially unchanged upon …

Natural killer (NK) cells, the CD3-CD56+ CD16+ subset of peripheral blood lymphocytes,
have long been known to be involved in non-major histocompatibility complex-restricted …

The adult liver contains lymphocytes with a unique phenotypic distribution compared to
blood and other organs. We have characterized a human lymphocyte population that …