Chronic myeloid leukemia—advances in biology and new approaches to treatment
JM Goldman, JV Melo - New England Journal of Medicine, 2003 - Mass Medical Soc
An extraordinary series of discoveries about chronic myeloid leukemia (CML) has made this
disease a model of the way in which bench and bedside research can unite and culminate …
disease a model of the way in which bench and bedside research can unite and culminate …
Getting to the stem of chronic myeloid leukaemia
M Savona, M Talpaz - Nature Reviews Cancer, 2008 - nature.com
Tyrosine kinase inhibitor (TKI) therapy for chronic myeloid leukaemia (CML) is the
consummate success story for targeted therapy, yet relapse is a nearly inevitable …
consummate success story for targeted therapy, yet relapse is a nearly inevitable …
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
M Copland, A Hamilton, LJ Elrick, JW Baird, EK Allan… - Blood, 2006 - ashpublications.org
Abstract Dasatinib (BMS-354825), a novel dual SRC/BCR-ABL kinase inhibitor, exhibits
greater potency than imatinib mesylate (IM) and inhibits the majority of kinase mutations in …
greater potency than imatinib mesylate (IM) and inhibits the majority of kinase mutations in …
Early reduction of BCR-ABL mRNA transcript levels predicts cytogenetic response in chronic phase CML patients treated with imatinib after failure of interferon α
K Merx, MC Müller, S Kreil, T Lahaye, P Paschka… - Leukemia, 2002 - nature.com
The degree of tumor load reduction as measured by cytogenetic response is an important
prognostic factor for chronic myelogenous leukemia (CML) patients on therapy. We sought …
prognostic factor for chronic myelogenous leukemia (CML) patients on therapy. We sought …
Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasia arising from the
oncogenic break point cluster region/Abelson murine leukemia viral oncogene homolog 1 …
oncogenic break point cluster region/Abelson murine leukemia viral oncogene homolog 1 …
[HTML][HTML] Mixed-phenotype acute leukemia: suboptimal treatment when the 2008/2016 WHO classification is used
A Pomerantz, S Rodriguez-Rodriguez… - Blood …, 2016 - ncbi.nlm.nih.gov
Background Different criteria have been used to diagnose mixed-phenotype acute leukemia
(MPAL), which has impacted the number of individuals diagnosed with this pathology. Better …
(MPAL), which has impacted the number of individuals diagnosed with this pathology. Better …
FISH for BCR-ABL on interphases of peripheral blood neutrophils but not of unselected white cells correlates with bone marrow cytogenetics in CML patients treated …
U Reinhold, E Hennig, S Leiblein, D Niederwieser… - Leukemia, 2003 - nature.com
Interphase fluorescence in situ hybridization (I-FISH) for the BCR-ABL translocation
performed on peripheral blood (PB) white cells has been suggested as a surrogate for …
performed on peripheral blood (PB) white cells has been suggested as a surrogate for …
Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells
SD Turner, DR Alexander - Leukemia, 2006 - nature.com
The fusion tyrosine kinases (FTKs) are generated by chromosomal translocations creating
bipartite proteins in which the kinase is hyperactivated by an adjoining oligomerization …
bipartite proteins in which the kinase is hyperactivated by an adjoining oligomerization …
New strategies in the chemotherapy of leukemia: eradicating cancer stem cells in chronic myeloid leukemia
A Stefanachi, F Leonetti, O Nicolotti… - Current cancer drug …, 2012 - ingentaconnect.com
Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by the Philadelphia-
positive chromosome deriving from a translocation between chromosomes 22 and 9. The …
positive chromosome deriving from a translocation between chromosomes 22 and 9. The …
Persistence of transcriptionally silent BCR-ABL rearrangements in chronic myeloid leukemia patients in sustained complete cytogenetic remission
A Kitzis, F Brizard, C Dascalescu, JC Chomel… - Leukemia & …, 2001 - Taylor & Francis
Persistence of BCR-ABL rearrangements was demonstrated by D-FISH technique in chronic
myeloid leukemia (CML) patients in complete cytogenetic response (CCR) after allogeneic …
myeloid leukemia (CML) patients in complete cytogenetic response (CCR) after allogeneic …