The extracellular matrix is a critical component of microbial biofilms, such as dental plaque,
maintaining the spatial arrangement of cells and coordinating cellular functions throughout …

Host innate and adaptive immunity to infection with Streptococcus pneumoniae is critically
dependent on the complement system, demonstrated by the high incidence of invasive S …

We aimed to clarify the epidemiologic and clinical importance of evolutionary events that
occurred in carbapenem-resistant Klebsiella pneumoniae (CRKP). We collected 203 CRKP …

Naturally acquired immunity against invasive pneumococcal disease (IPD) is thought to be
dependent on anti-capsular antibody. However nasopharyngeal colonisation by …

Expression of a capsular polysaccharide is considered a hallmark of most invasive species
of bacteria, including Streptococcus pneumoniae, in which the capsule is among the …

The pneumococcal conjugate vaccine (PCV) strongly protects against vaccine serotypes,
but the rapid expansion of non-vaccine serotype disease and the vaccine's high expense …

In this review, we address the interplay between the complement system and host
microbiomes in health and disease, focussing on oral bacteria known to contribute to …

Despite vaccines, Streptococcus pneumoniae kills more than a million people yearly. Thus,
understanding how pneumococci transition from commensals to pathogens is particularly …

Streptococcus pneumoniae's polysaccharide capsule is an important virulence factor;
vaccine-induced immunity to specific capsular polysaccharide effectively prevents disease …

Streptococcus pneumoniae is a Gram-positive, encapsulated bacterium that is a significant
cause of disease burden in pediatric and elderly populations. The rise in unencapsulated …