Mendelian randomization (MR) is increasingly used to make causal inferences in a wide
range of fields, from drug development to etiologic studies. Causal inference in MR is …

During development, the human fetus accrues the highest proportion of fat of all mammals.
Precursors of fat lobules can be found at week 14 of pregnancy. Thereafter, they expand …

Background Epidemiological studies report associations of diverse cardiometabolic
conditions including obesity with COVID-19 illness, but causality has not been established …

Background Increasing evidence from observational studies and clinical experimentation
has indicated a link between the gut microbiotas (GMs) and polycystic ovary syndrome …

Importance Lower educational attainment is associated with increased risk of adverse
pregnancy outcomes, but it is unclear which pathways mediate this association. Objective To …

Purpose The effect of hyperglycemia on periodontitis is mainly based on observational
studies, and inconsistent results were found whether periodontal treatment favors glycemic …

Parkinson's disease (PD) is a late-onset and genetically complex neurodegenerative
disorder. Here we sought to identify genes and molecular pathways underlying the …

Diseases diagnosed in adulthood may have antecedents throughout (including prenatal)
life. Gaining a better understanding of how exposures at different stages in the lifecourse …

Mendelian randomization (MR) is an increasingly popular approach to estimating causal
effects. Although the assumptions underlying MR cannot be verified, they imply certain …

Introduction Psoriasis is a chronic inflammatory disease of the skin. A few studies have
shown that psoriasis is an immune-mediated disease in which multiple immune cells play …