T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The discovery of CD4+ T cell subset–defining master transcription factors and framing of the
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …

Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of
lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly …

A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …

The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR)
are crucial to our understanding of immunity and the harnessing of T cells therapeutically. A …

Combining whole exome sequencing, transcriptome profiling, and T cell repertoire analysis,
we investigate the spatial features of surgically-removed biopsies from multiple loci in tumor …

Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many
patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based …

T cells undergo positive and negative selection in the thymic cortex and medulla,
respectively. A promiscuous expression of a wide array of self-antigens in the thymus is …

Cell-based drug delivery systems (DDSs) have received attention recently because of their
unique biological properties and self-powered functions, such as excellent biocompatibility …

Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …