The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-
specific cell behaviour. The molecules that are associated with the ECM of each tissue …

The composition and organisation of the extracellular matrix (ECM), particularly the
pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the …

Cardiomyocyte proliferation stops at birth when the heart is no longer exposed to maternal
blood and, likewise, to regulatory T cells (Tregs) that are expanded to promote maternal …

Vitamin K is a cofactor for the function of the enzyme γ-glutamyl carboxylase, necessary for
the activation of multiple vitamin K dependent-proteins. Vitamin K dependent-proteins …

Osteoarthritis (OA) is among the most frequent diseases of the musculoskeletal system.
Degradation of cartilage extracellular matrix (ECM) is a hallmark of OA. During the …

Cartilage oligomeric matrix protein (COMP) is an abundant component in the extracellular
matrix (ECM) of load-bearing tissues such as tendons and cartilage. It provides adaptor …

Exercise plays a critical role in regulating glucose homeostasis and body weight. However,
the mechanism of exercise on metabolic functions associated with the CNS has not been …

Abstract Mutant matrilin-3 (V194D) forms non-native disulphide bonded aggregates in the
rER of chondrocytes from cell and mouse models of multiple epiphyseal dysplasia (MED) …

Blue mussels adhere to surfaces by the byssus, a holdfast structure composed of individual
threads representing a collagen fibre reinforced composite. Here, we present the crystal …

Proteins have been widely used in the biomedical field because of their well-defined
architecture, accurate molecular weight, excellent biocompatibility and biodegradability, and …