Tuberculosis IRIS: pathogenesis, presentation, and management across the spectrum of disease

CM Quinn, V Poplin, J Kasibante, K Yuquimpo… - Life, 2020 - mdpi.com
Antiretroviral therapy (ART), while essential in combatting tuberculosis (TB) and HIV
coinfection, is often complicated by the TB-associated immune reconstitution inflammatory …

Use of Xpert MTB/RIF and Xpert Ultra in extrapulmonary tuberculosis

M Park, OM Kon - Expert review of anti-infective therapy, 2021 - Taylor & Francis
Introduction Tuberculosis (TB) remains a major global health burden. There still remains a
large gap between the notified and estimated incident cases. Extrapulmonary (EP) TB …

Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study

FV Cresswell, L Tugume, NC Bahr… - The Lancet infectious …, 2020 - thelancet.com
Introduction Tuberculous meningitis accounts for 1–5% of tuberculosis cases. Diagnostic
delay contributes to poor outcomes. We evaluated the performance of the new Xpert …

Southern African HIV Clinicians Society guideline for the prevention, diagnosis and management of cryptococcal disease among HIV-infected persons: 2019 update

NP Govender, G Meintjes, P Mangena, J Nel… - … African journal of HIV …, 2019 - scielo.org.za
Background Early diagnosis of HIV infection and early initiation of ART before
immunosuppression is the most important strategy to reduce the incidence of CM and CM …

Fulminant central nervous system varicella-zoster virus infection unexpectedly diagnosed by metagenomic next-generation sequencing in an HIV-infected patient: a …

M Fang, X Weng, L Chen, Y Chen, Y Chi, W Chen… - BMC infectious …, 2020 - Springer
Background Varicella-zoster virus (VZV) infection can be diagnosed clinically once classical
rash occurs but the diagnosis is challenging when typical rash is absent. We reported a case …

Standardized urine-based tuberculosis (TB) screening with TB-lipoarabinomannan and Xpert MTB/RIF Ultra in Ugandan adults with advanced human …

FV Cresswell, J Ellis, E Kagimu… - Open forum …, 2020 - academic.oup.com
Background Diagnosis of extrapulmonary tuberculosis (TB) remains challenging. We sought
to determine the prevalence of disseminated TB by testing urine with TB-lipoarabinomannan …

Tuberculosis-associated immune reconstitution inflammatory syndrome—an extempore game of misfiring with defense arsenals

R Vignesh, P Balakrishnan, HY Tan, YK Yong, V Velu… - Pathogens, 2023 - mdpi.com
The lethal combination involving TB and HIV, known as “syndemic” diseases, synergistically
act upon one another to magnify the disease burden. Individuals on anti-retroviral therapy …

The Th2 Response and Alternative Activation of Macrophages Triggered by Strongyloides venezuelensis Is Linked to Increased Morbidity and Mortality Due to …

L Gouveia-Eufrasio, GJC de Freitas, MC Costa… - Journal of Fungi, 2023 - mdpi.com
Cryptococcosis is a systemic mycosis that causes pneumonia and meningoencephalitis.
Strongyloidiasis is a chronic gastrointestinal infection caused by parasites of the genus …

Tuberculosis in HIV-associated cryptococcal meningitis is associated with an increased risk of death

MK Rutakingirwa, FV Cresswell, R Kwizera… - Journal of Clinical …, 2020 - mdpi.com
Tuberculosis (TB) and cryptococcal meningitis are leading causes of morbidity and mortality
in advanced HIV disease. Data are limited on TB co-infection among individuals with …

Neurotuberculosis: a clinical review

JH Chin - Seminars in Neurology, 2019 - thieme-connect.com
In September 2018, the United Nations General Assembly held the first ever meeting to
discuss the global epidemic of tuberculosis (TB) and adopted a political declaration titled …